This trial is active, not recruiting.

Condition turner syndrome
Sponsor University of Aarhus
Start date August 2003
End date June 2012
Trial size 102 participants
Trial identifier NCT00624949, 20010248


An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
women with Turner syndrome
Control women

Primary Outcomes

Aortic diameter at 3 well-defined levels measured by MRI and ECHO
time frame: 2-yearly for 6 years

Secondary Outcomes

24hour ambulatory blood pressure
time frame: 24h 2-yearly for 6 years

Eligibility Criteria

Female participants from 18 years up to 70 years old.

Inclusion Criteria: - Turner syndrome - Age 18-70 years Exclusion Criteria: - Extreme adipositas - Contraindications to a MRI scan - Malignant disease

Additional Information

Official title Aortic Dimensions, 24hour Ambulatory Blood Pressure and Sympathovagal Tone in Turner Syndrome. In Relation to Aortic Dilatation and Dissection.
Trial information was received from ClinicalTrials.gov and was last updated in February 2008.
Information provided to ClinicalTrials.gov by University of Aarhus.