Comparison of Nylon Flocked Swabs and Saline Aspirates for Detection Respiratory Viruses
This trial is active, not recruiting.
|Conditions||respiratory syncytial virus, human metapneumovirus, influenza, bronchiolitis, pediatric|
|Treatments||nylon flocked swab (nasal secretion sampling)|
|Sponsor||Kern Medical Center|
|Collaborator||Medical Diagnostic Laboratories, LLC|
|Start date||November 2006|
|End date||January 2008|
|Trial size||150 participants|
|Trial identifier||NCT00613184, kmc06037|
Collection of nasal secretions from infants and toddlers for viral testing is usually done using the nasal washing technique described by Hall in 1975. This is cumbersome. Previous attempts to use swabs have been unsuccessful because the swabs didn't work well. A newly designed swab may work better and in this study we compare the new swab with the old style nasal washing.
|Endpoint classification||efficacy study|
|Intervention model||crossover assignment|
Viral detection rate by PCR
time frame: 0 not applicable
Male or female participants up to 18 months old.
Inclusion Criteria: - Treating clinican ordered RSV antigen testing Exclusion Criteria: - Refusal of consent - Age > 18 months
|Official title||Comparison of Nylon Flocked Swabs and Saline Aspirates for Detection Respiratory Viruses|
|Principal investigator||Paul Walsh, MD|
|Description||Collection of nasal secretions from infants and toddlers for viral testing is typically performed using the nasal saline aspirate technique described by Hall in 1975. Nylon flocked swabs (NFS) and universal transport medium for room temperature (UTM-RT) (Copan Medical, Murrieta, CA) storage media have been found to be an effective collection and transport method for bacteria causing sexually transmitted infections. We adapted these swabs and storage medium to collect respiratory viruses from children less than18 months old and compared detection rates using NFS and traditional nasal aspirates. We will determine the relative roles of the UTM-RT and NFS release and therefore measured viral detection rates of common respiratory pathogens in traditional saline aspirates stored in UTM-RT. Our primary hypothesis is that nasal secretions collection using NFS stored in UTM-RT will lead to a higher detection rate of the respiratory viruses we arestudying; namely RSV, Influenza and human metapneumovirus from than collection of unpreserved saline nasal aspirates in children less than 18 months of age.|
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