This trial is active, not recruiting.

Conditions coronary artery disease, arteriovenous malformations, myocardial infarction
Sponsor The Cleveland Clinic
Collaborator National Heart, Lung, and Blood Institute (NHLBI)
Start date January 1995
End date December 2015
Trial size 2980 participants
Trial identifier NCT00590291, 1 P50 HL077107-03, GeneQuest, IRB4333


The purpose of this study is to discover genes that may cause Coronary Artery Disease (CAD) or Arteriovenous Malformation (AVM).

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model family-based
Time perspective retrospective
premature CAD and MI, AVM

Primary Outcomes

Coronary Artery Disease
time frame: 2009
Arteriovenous Malformation
time frame: 2009

Secondary Outcomes

Myocardial Infarction
time frame: 2009

Eligibility Criteria

Male or female participants at least 45 years old.

Inclusion Criteria: - Males at least 45 years old and premenopausal females at least 50 years old at the time of onset of any of the following: - PTCA - MI - CABG - Must have a living sibling meeting the same criteria. Exclusion Criteria: - Substance Abuse in the absence of angiographic coronary stenosis - Congenital Heart Disease

Additional Information

Official title Genetic Studies of Coronary Artery Disease and Arteriovenous Malformation (GeneQuest) Molecular Determinants of Coronary Artery Disease
Principal investigator Qing Wang, PhD
Description The purpose of this study is to discover genes that may cause Coronary Artery Disease (CAD) or Arteriovenous Malformation (AVM). Many human diseases are inherited or passed from parent to child in families. These diseases occur because of damage to a gene(s), the genetic material that is also called DNA. Scientists can now use modern molecular techniques to locate and to find certain genes within the DNA (genetic material) of a person, and to follow their inheritance in a family. To find these disease-causing genes requires studies of many affected with the disease and their family members. The purpose of this study is to locate and to find the genes for coronary artery disease (CAD) which occurs when one or more of the arteries that carry oxygen-rich blood from your heart to the rest of your body develop blockages; or, arteriovenous malformation (AVM) which causes abnormal vascular connections between arteries and veins, particularly near the heart. Findings of the genes causing CAD and AVM will have far-reaching effect on the diagnosis, treatment, and prevention of coronary artery disease and arteriovenous malformation. These studies will lead to possible genetic diagnosis, early detection of persons at risk for developing CAD or AVM (even in the absence of symptoms), development of effective drugs, more rational and specific therapeutic interventions, treatments and ultimately, prevention of coronary heart disease. Approximately 3-5 years are required to find one human disease gene.
Trial information was received from ClinicalTrials.gov and was last updated in January 2012.
Information provided to ClinicalTrials.gov by The Cleveland Clinic.