This trial is active, not recruiting.

Condition hypertrophic cardiomyopathy
Sponsor The Cleveland Clinic
Start date June 2005
End date December 2008
Trial size 40 participants
Trial identifier NCT00589836, IRB 05-023


The purpose of this study is to learn about the twisting or wringing motion of the heartbeat called torsion which can be seen on ultrasound. This study will help figure out if there is a difference in the how a heart twists at rest and with exercise in people with normal hearts compared to people with HCM (abnormally thickened heart muscle). Volunteers will have an echocardiogram (ultrasound of the heart) while lying on a bed both at rest and while peddling a wheel located at at the foot of the bed. The patients will take about 1 to 1 1/2 hours total and the study will be complete after this procedure.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model case control
Time perspective cross-sectional
Patients with structurally normal hearts
Patients with hypertrophic cardiomyopathy

Primary Outcomes

Myocardial torsion as measured by tissue Doppler echocardiography
time frame: 1 1/2 hours

Eligibility Criteria

Male or female participants from 18 years up to 70 years old.

Inclusion Criteria: - Male and female patients age 18 to 70 years - Patients with hypertrophic cardiomyopathy - Patients with the ability to exercise using a supine bicycle - Ability to provide informed consent Exclusion Criteria: - Aortic valve stenosis classified as moderate to severe - Severe left ventricular obstruction at rest (high gradients > 4m/second) - Uncontrolled arrhythmias including atrial fibrillation, atrial flutter, frequent premature ventricular ectopic beats - History of sustained ventricular tachyarrhythmia at any time

Additional Information

Official title Assessment of LV Torsion by Tissue Doppler Echocardiography
Principal investigator Zoran Popovic, M.D.
Description Left ventricular myocardial torsion (myocardial wringing motion) will be investigated by the use of tissue Doppler echocardiography in both normal and HCM (hypertrophic cardiomyopathy) patients. The objective of this study is to characterize the myocardial torsional behavior in normal and in HCM patients both at rest and while undergoing moderate physiological exercise. After a routine echocardiographic study, tissue Doppler echocardiogram will be performed before and during supine bicycle exercise. Stress EchoTM Bed with ergometer (supine bicycle) is used during exercise testing. Standard electrocardiogram and blood pressure will be monitored throughout the exercise testing. This procedure will take about 1 to 1 1/2 hours and will not involve any follow-up.
Trial information was received from ClinicalTrials.gov and was last updated in October 2008.
Information provided to ClinicalTrials.gov by The Cleveland Clinic.