This trial is active, not recruiting.

Condition unspecified complication of lung transplant
Sponsor The University of Texas Medical Branch, Galveston
Start date August 2007
End date December 2015
Trial size 10 participants
Trial identifier NCT00584181, 07-247


Lung and heart-lung recipients at the University of Texas Medical Branch who have participated in the "Assessment of Cough Reflex in Lung Transplant Recipients" study who meet the specific study inclusion/exclusion criteria will have one study visit where they will undergo lung volume measurements, followed by high resolution CT scan of the lungs within 2 hours. After the initial CT scan, patients will be given a standard dose of Atrovent, followed thirty minutes later by repeat lung volume measurements and CT scan.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
All eligible patients will undergo the same procedures

Primary Outcomes

Spirometry changes
time frame: Two hours (before and after inhalation of ipratropium)

Secondary Outcomes

Lung volumes
time frame: Two hours (before and after inhalation of ipratropium)

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - lung transplant recipients >18 years of age - at least 12 months or greater from time of transplantation Exclusion Criteria: - hemodynamic instability - hypoxemia - pneumonia - moderate or large pleural effusion - clinical evidence of acute rejection

Additional Information

Official title High Resolution Computed Tomographic Evaluation of Airway Distensibility in Lung Transplant Recipients: A Pilot Study
Principal investigator Alexander G Duarte, MD
Trial information was received from ClinicalTrials.gov and was last updated in August 2015.
Information provided to ClinicalTrials.gov by The University of Texas Medical Branch, Galveston.