This trial is active, not recruiting.

Condition colorectal cancer
Sponsor Memorial Sloan Kettering Cancer Center
Start date February 1998
End date December 2017
Trial size 337 participants
Trial identifier NCT00582335, 98-003


The purpose of this study is to define new genes for family risks of developing colon cancer.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model family-based
Time perspective prospective

Primary Outcomes

Evidence of mutations in selected candidate genes
time frame: 10 years 10 months

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Age 18 years or greater - Able to provide informed consent - Any family in which a minimum of two first-degree relatives either are, or have previously been, affected with primary colorectalcancer. These "minimum inclusion criteria" must be met within three generations of the proband or kindreds in which colorectal cancer and lymphoma or renal cell cancer are present or in kindreds in which lymphoma alone or lymphoma and renal cell cancer are present Exclusion Criteria: - Age less than 18 years - Family not at increased risk for familial colorectal cancer (see Section 4.1) - Family with a hereditary polyposis syndrome (e.g. classic FAP) - Not able to provide informed consent

Additional Information

Official title Identification of New Colorectal Cancer Genes
Principal investigator Kenneth Offit, MD
Description Colorectal cancer is one of the most significant causes of cancer morbidity and mortality in the United States. In 1997, approximately 130,000 men and woman were diagnosed with colorectal cancer (fourth most common cancer site) and approximately 55,000 died of this disease (second most common cause of cancer deaths); (Cancer Facts & Figures, 1997). Genetic factors clearly contribute to the etiology of colorectal cancer. Because there is evidence to suggest genetically determined susceptibility to colorectal cancer exists in a proportion of newly diagnosed cases each year, we are conducting a study to identify new genes that are associated with an increased susceptibility to familial colorectal cancer by analysis of families with a clustering of colorectal cancers.
Trial information was received from ClinicalTrials.gov and was last updated in January 2017.
Information provided to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center.