Acute Salt Handling in Orthostatic Intolerance
This trial is active, not recruiting.
|Conditions||postural tachycardia syndrome, orthostatic tachycardia, orthostatic intolerance|
|Treatment||normal saline (0.9%)|
|Collaborator||National Institutes of Health (NIH)|
|Start date||February 2007|
|End date||December 2014|
|Trial size||30 participants|
|Trial identifier||NCT00581633, 061230, NIH 1 UL1 RR024975, NIH K23 RR020783, NIH P01 HL 56693|
The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control subjects.
|Endpoint classification||pharmacokinetics study|
|Intervention model||parallel assignment|
saline infusion for sodium loading
Urinary Na excretion
time frame: 24h and then hourly post saline load
time frame: 1 day
Male or female participants from 18 years up to 65 years old.
Inclusion Criteria: - Diagnosed with orthostatic intolerance by Vanderbilt Autonomic Dysfunction Center (or healthy control subject) Exclusion Criteria: - Overt or acute cause for orthostatic tachycardia - Hypertension (BP>145/95 or need for anti-hypertensive medications) - QRS duration > 120 msec on EKG - Pregnancy
|Official title||Acute Renal Salt Handling in Orthostatic Intolerance|
|Principal investigator||Satish R Raj, MD MSCI|
|Description||Patients with chronic OI appear to be hypovolemic with abnormalities in hormones that regulate salt & water handling. Increases in dietary salt have salutary effects on orthostatic tolerance in a physiological laboratory. The infusion of intravenous saline acutely decreased heart rate in this patient population. Preliminary data from Vanderbilt suggests abnormal salt handling in patients with chronic OI in a few patients. These data need to be confirmed and a better understanding of sodium handling in response to acute salt loads is required in these patients.|
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