Water and the Gastropressor Response - Tachyphylaxis
This trial is active, not recruiting.
|Treatments||water high dose, water tiny dose|
|Sponsor||Satish R. Raj|
|Start date||July 2006|
|End date||December 2018|
|Trial size||20 participants|
|Trial identifier||NCT00580996, 060547, Vanderbilt Discovery|
We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.
|Intervention model||crossover assignment|
16 oz water in AM
water 1 oz in AM
time frame: 2nd water intervention
time frame: 2nd intervention
All participants from 18 years up to 80 years old.
Inclusion Criteria: - orthostatic hypotension (fall in BP>20/10 mmHg) - pressor response to water in other studies - Age 18-80 years Exclusion Criteria: - pregnancy
|Official title||Water and the Gastropressor Response - Tachyphylaxis (Specific Aim 1.2)|
|Principal investigator||Satish R Raj, MD MSCI|
|Description||We are studying the effects of oral water ingestion in patients with orthostatic hypotension. This has been termed the Gastropressor Response. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16 oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will be given to start, with 16 oz again as the second dose.|
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