The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior
This trial is active, not recruiting.
|Condition||smoking lapse behavior|
|Treatments||varenicline, bupropion, placebo|
|Collaborator||National Institute on Alcohol Abuse and Alcoholism (NIAAA)|
|Start date||April 2007|
|End date||July 2016|
|Trial size||60 participants|
|Trial identifier||NCT00580853, HIC0702002390, P50AA015632|
The purpose of this study is to examine how smoking cessation medications (varenicline, bupropion) affect the ability to resist smoking and also subsequent ad-lib smoking in non-treatment seeking daily smokers.
|Intervention model||factorial assignment|
|Masking||double blind (subject, investigator, outcomes assessor)|
latency to initiate ad-lib smoking session
time frame: in the laboratory session
number of cigarettes smoked during the ad-lib period
time frame: during the laboratory session
Male or female participants from 21 years up to 55 years old.
Inclusion Criteria: - ages 18-55 - able to read and write in English - Smokers Exclusion Criteria: - any significant current medical or psychiatric conditions that would contraindicate smoking - current DSM-IV abuse or dependence of other substances, other than nicotine dependence or alcohol abuse - positive test result at intake appointments on urine drug screens conducted for opiates, cocaine, or benzodiazepines - women who are pregnant or nursing - suicidal, homicidal, or evidence of current severe mental illness - participants prescribed any psychotropic drug in the 30 days prior to study enrollment - blood donation within the past 6 weeks - individuals seeking treatment for smoking cessation or have attempted to quit smoking within the past 3 months - specific exclusions for bupropion administration not already specified, including: have taken monoamine inhibitors in the past 6 weeks; history of anorexia or bulimia; previous hypersensitivity to bupropion; history of alcohol or drug dependence in the past year; history of seizure disorder of any etiology - known allergy to varenicline or taking H2blockers - participation within the past 8 weeks in other studies that involve additive blood sampling and/or interventional measures that would be considered excessive in combination with the current study
|Official title||The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior|
|Principal investigator||Sherry A McKee, PhD|
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