Overview

This trial is active, not recruiting.

Condition osteoarthritis
Treatment myalgesin™ (celery seed extract, boswellia serrata extract, phellodendron extract)
Phase phase 3
Sponsor ProThera, Inc.
Start date May 2006
End date January 2008
Trial size 110 participants
Trial identifier NCT00577330, 20052687, MYG-01-2006

Summary

Myalgesin is a botanical preparation consisting of celery seed extract,extract of dried Boswellia serrata, and dried extract of Phellodendron bark. Component of these extracts have been shown to exert anti-inflammatory effects and to inhibit cyclooxygenase and 5-lipooxygenase. The study is based on the hypothesis that oral administrration of this botanical will support joint function in people with osteoarthritis of the knee and improve symptoms and mobility as measured by the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification safety/efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment
Arm
(Experimental)
Subjects receive Myalgesin twice daily
myalgesin™ (celery seed extract, boswellia serrata extract, phellodendron extract)
Twice daily
(Active Comparator)
Subjects receive acetaminophen 1000 mg three times a day
myalgesin™ (celery seed extract, boswellia serrata extract, phellodendron extract)
Twice daily

Primary Outcomes

Measure
Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index
time frame: 90 days

Secondary Outcomes

Measure
Lesquesne Algofunctional Index
time frame: 90 days

Eligibility Criteria

Male or female participants at least 50 years old.

Inclusion Criteria: - Men and women age 50-years or older. - Patients with symptomatic osteoarthritis of the knees as defined by the American College of Rheumatology criteria(traditional format). - At least moderate pain in the knee (rated at 40 or greater by the subject on a visual analogue scale) for most days during the last month. - Use of analgesic or anti-inflammatory agents for control of pain for at least 1 month. - Baseline functional capacity class 1 to 3, in which class 1 is complete ability to carry out usual activities without handicap,class 2 is ability to adequately conduct usual activities despite handicap of discomfort or limited mobility of one or more joints,and class 3 is limited ability to carry out usual activities. (American Rheumatism Association functional class) - Documented radiographic changes of osteoarthritis on a previous knee radiograph (Kellgren-Lawrence grade of 2 or more). Exclusion Criteria: - Age <50-years. - Body mass index (BMI) equal to or greater than 35 kg/m2. - Baseline functional class 4 with the subject bedridden or confined to wheelchair, largely or wholly incapacitated and capable of little or no self-care. (American Rheumatism Association functional class) - Inflammatory arthritis, gout, pseudogout, or Paget's disease. - Presence of chronic pain syndromes, such as fibromyalgia or reflex sympathetic dystrophy, that may interfere with the assessment of joint symptomatology. - Severe bursitis of the knee. - History of acute joint trauma within 30 days of study entry. - Complete loss of articular cartilage. - History of total knee replacement. - Intra-articular/intramuscular corticosteroids within 30 days of study entry. - Intra-articular hyaluronan and hyalans within 30 days of study entry. - History of gastrointestinal bleeding within 1 year of study entry. - Active peptic ulcer disease, gastroesophageal reflux disease, or inflammatory bowel disease. - Gastrointestinal tract ulceration within 30 days of study entry. - Severe renal dysfunction defined as a serum creatinine greater than 2 mg/dL. - Clinically significant liver disease including an aspartate aminotransferase or alanine aminotransferase >2 times the upper limit of normal. - Unwillingness or inability to abstain from ethanol for the study duration. - Significant bleeding disorder. - History of gastric or duodenal surgery. - Warfarin use. - Sensitivity to acetaminophen or to any of the components of Myalgesin™. - Pregnancy. - Any serious medical, social or psychological condition that, in the opinion of the Principal Investigator, would disqualify a subject from participation.

Additional Information

Official title The Efficacy of Myalgesin™ for the Support of Joint Function in Patients With Osteoarthritis of the Knee — A Prospective Randomized Controlled Study
Principal investigator Stuart I Erner, MD
Trial information was received from ClinicalTrials.gov and was last updated in December 2007.
Information provided to ClinicalTrials.gov by ProThera, Inc..