Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity
This trial is active, not recruiting.
|Conditions||pregnancy complications, preeclampsia, placental abruption, intrauterine fetal growth restriction, intrauterine fetal death|
|Sponsor||Tel-Aviv Sourasky Medical Center|
|Start date||January 2000|
|End date||January 2008|
|Trial size||100 participants|
|Trial identifier||NCT00573118, FactorVIII|
Congenital and acquired thrombophilia were identified as risk factors for thrombosis in systemic vessels.Thrombophilias have also been recently found to be associated with preeclampsia, intrauterine fetal growth restriction (IUGR), placental abruption, intrauterine fetal death (IUFD) and repeated pregnancy loss.These severe pregnancy complications are thought to result from thrombotic events occurring in the uteroplacental circulation. Accumulating data have established an association between elevated plasma activity of factor VIII and thrombosis although the mechanism is still not defined and elevated factor VIII activity is now regarded as being equivalent to thrombophilia.
We intend to investigatthe association between factor VIII levels and severe pregnancy complications which are considered to result from placental vascular pathology, i.e., preeclampsia, IUGR, placental abruption and IUFD. We hypothezise that the prevalence of elevated factor 8 will be higher among women with pregnancy complications compared to controls.
|Observational model||case control|
prevalenc of elevated factor VIII
time frame: RETROSPECTIVE
Female participants from 18 years up to 45 years old.
- Women who had either normal pregnancy or complicated pregnancy.
- Other causes of pregnancy complication such as infections, anomalies and fetal malformations
|Official title||A Retrospective Analysis of Possible Association Between Severe Pregnancy Complications and Elevated Factor VIII Plasma Activity.|
|Principal investigator||Eli Rimon, MD|
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