Overview

This trial is active, not recruiting.

Conditions breast cancer, bone metastases
Treatments dasatinib, zoledronic acid
Phase phase 1/phase 2
Target BCR-ABL
Sponsor M.D. Anderson Cancer Center
Collaborator Bristol-Myers Squibb
Start date November 2007
End date March 2016
Trial size 28 participants
Trial identifier NCT00566618, 2006-0900, NCI-2010-01575

Summary

The goal of this clinical research study is to find the highest tolerable dose of dasatinib and Zometa (zoledronic acid) that can be given in combination for the treatment of breast cancer that has spread to the bone. The safety and effectiveness of this combination will also be studied.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Endpoint classification safety/efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment
Arm
(Experimental)
Dasatinib Phase I: First Cohort = 100 mg PO Daily x 28 days; Next Cohort = Dose Expansion or Reduction Based on Dose Limiting Toxicity (DLT) in Initial Cohort. Zoledronic Acid Phase I: First Cohort = 4 mg IV Over 15 min. every 4 Weeks; Next Cohort = Dose Expansion or Reduction Based on Dose Limiting Toxicity (DLT) in Initial Cohort. Phase II: Recommended Phase II Dose (RP2D) as determined with Phase I.
dasatinib BMS-345825
Phase I: First Cohort = 100 mg PO Daily x 28 days; Next Cohort = Dose Expansion or Reduction Based on Dose Limiting Toxicity (DLT) in Initial Cohort. Phase II: Recommended Phase II Dose (RP2D) as determined with Phase I.
zoledronic acid Zoledronate
Phase I: First Cohort = 4 mg IV Over 15 min. every 4 Weeks; Next Cohort = Dose Expansion or Reduction Based on Dose Limiting Toxicity (DLT) in Initial Cohort. Phase II: Recommended Phase II Dose (RP2D) as determined with Phase I.

Primary Outcomes

Measure
Maximum Tolerated Dose (MTD)
time frame: Continous reassessment with each dose level (28 day cycle)

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: 1. Patients must have a pathologically confirmed diagnosis of invasive carcinoma of the breast. 2. Patients must carry a diagnosis of metastatic breast cancer with predominant bone involvement. For the purposes of this study, predominant bone involvement will be defined as radiographically detected bone metastasis in the presence or absence of other sites of metastatic breast cancer (i.e. visceral involvement). If visceral involvement is present, patients must be asymptomatic and have no tumors in visceral organs that measure >3cm in size. 3. Patients must agree to serial urine collections for measurement of Ntx. 4. Age >/= 18 years. 5. Patients must be able to swallow oral medications. Dasatinib must be taken whole and cannot be crushed. 6. Patients must have evaluable disease using WHO Criteria for Assessment of Disease Response in Bone or MDACC Modified Response Criteria for Assessment of Disease Response in Bone. 7. Patients must not have had >1 chemotherapy regimens for metastatic disease. Patients with metastasis diagnosed /= 1,500/mcL, Platelet count >/= 100,000/mcL, Bilirubin /= Lower Limit of Normal (LLN) [subjects with low electrolyte levels must be repleted to normal for protocol entry] 18. Patients must not receive any concurrent bisphosphonate therapy other than that prescribed by the study. 19. Sexually active patients with reproductive potential must agree to use an effective method of birth control during the course of the study and for no less than 4 weeks after discontinuing study drug. Contraceptives must be used in a manner such that risk of failure is minimized. Oral contraceptives should be avoided in women with estrogen or progesterone receptor positive breast cancer. 20. Prior to study enrollment, women of childbearing potential (WOCBP) must be advised of the importance of avoiding pregnancy during trial participation and the potential risk factors for an unintentional pregnancy. In addition, men enrolled on this study should understand the risks to any sexual partner of childbearing potential and should practice an effective method of birth control. 21. All WOCBP MUST have a negative serum or urine pregnancy test within 72 hours prior to the start of study drug administration. If the pregnancy test is positive, the patient must not receive investigational product and must not be enrolled in the study. 22. Patients with disease progression while receiving previous therapy in combination with bisphosphonates (including zoledronic acid) will be considered eligible for protocol participation. Exclusion Criteria: 1. Any malignancy (other than breast cancer) that required radiotherapy or systemic treatment within the past 5 years. 2. Concurrent medical condition which may increase the risk of toxicity, including: Pleural or pericardial effusion of any grade, clinically-significant coagulation or platelet function disorder (e.g. known von Willebrand's disease) 3. Cardiac Symptoms, including the following: Uncontrolled angina, congestive heart failure or MI within (6 months), diagnosed congenital long QT syndrome, any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes), prolonged QTc interval on pre-entry electrocardiogram (> normal range), subjects with hypokalemia or hypomagnesemia if it cannot be corrected 4. History of significant bleeding disorder unrelated to cancer, including: diagnosed congenital bleeding disorders (e.g., von Willebrand's disease), diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies), ongoing or recent (/= 12.0 mg/dL (3.0 mmol/L) at Visit 1. The formula to be used is: Corrected serum calcium (mg/dL) = Patient's serum calcium (mg/dL) + [0.8 x Midrange Albumin (g/dL) - Patient's Albumin (g/dL)]. 4.0g/dL to be used for the Midrange Albumin 15. Serum creatinine greater than or equal to 1.5 times the institutional upper limits of normal or a creatinine clearance of <40 ml/min when calculated by the Cockcroft and Gault formula (see protocol text for formula)

Additional Information

Official title Phase I/II Study of Dasatinib in Combination With Zoledronic Acid for the Treatment of Breast Cancer With Bone Metastasis
Principal investigator Stacy Moulder, MD
Description The Study Drugs: Zoledronic acid is designed to strengthen the bone and prevent fractures or breaks in the bone. Dasatinib is designed to block (stop) cells responsible for the breakdown of bone. Study Groups: If you are found to be eligible to take part in this study, you will be enrolled in a group of at least 3 participants to begin receiving zoledronic acid and dasatinib. The dose of dasatinib you receive will depend on when you enrolled in this study. All participants will receive the same amount of zoledronic acid. The first group of participants will be treated with the lowest dose of dasatinib given in combination with zoledronic acid. Once the highest tolerable dose level is found, up to 25 additional participants will be enrolled at that dose level. This is called the Phase II portion of the study. Drug Administration: You will receive zoledronic acid through a needle in your vein on Day 1 over 15 minutes. You will take dasatinib by mouth daily for 28 days. Dasatinib should be taken on an empty stomach or after a light meal. Every 28 days is called a study "cycle." Study Visits for Participants in the Phase I Portion: On Day 1 of Cycle 1, you will have the following tests and procedures performed. - You will have a physical exam, including measurement of your vital signs. - You will have a performance status evaluation. - Blood (about 1-2 teaspoons) will be drawn for routine tests. - You will have an ECG. On Day 8 of Cycle 1, you will have the following tests and procedures performed. - Blood (about 1-2 teaspoons) will be drawn for routine tests. - You will have an ECG. On Day 15 of Cycle 1, you will have the following tests and procedures performed. - You will have a physical exam. - You will have a performance status evaluation. - Blood (about 1-2 teaspoons) will be drawn for routine tests. - You will have an ECG. On Day 21 of Cycle 1, you will have the following tests and procedures performed. - Your vital signs will be measured. - Blood (about 1-2 teaspoons) will be drawn for routine tests. - You will have an ECG. On Day 1 of Cycle 2, you will have an ECG. On Day 1 of all other cycles, you will have the following tests and procedures performed. - You will have a physical exam. - You will have a performance status evaluation. - Blood (about 1-2 teaspoons) will be drawn for routine tests. - You will have MRIs, CT scans, and/or x-rays to check the status of the disease. On Days 1 and 28 of Cycle 1 and then every 3rd month, urine will be collected over 24 hours to check for markers of bone loss. After Cycles 3, 6, 9 and so on, you will have CT scans, MRIs, and/or x-rays to check the status of the disease At all study visits, you will be asked about any drugs you may be taking and any side effects you may be experiencing. Study Visits for Participants in the Phase II Portion: On Day 1 of all cycles, you will have the following tests and procedures performed. - You will have a physical exam, including measurement of your vital signs. - You will have a performance status evaluation. - Blood (about 1-2 teaspoons) will be drawn for routine tests. On Days 1 and 28 of Cycle 1 and then every 3rd month, urine will be collected to check for markers of bone loss. After Cycles 2, 4, 6 and so on, you will have CT scans, MRIs, and/or x-rays to check the status of the disease. At all study visits, you will be asked about any drugs you may be taking and any side effects you may be experiencing. Length of Study: You may remain on study for as long as you are benefitting. You will be taken off study if the disease gets worse or you experience intolerable side effects. End-of-Study Visit: Once you go off-study, you will have an end-of-study visit. - Your vital signs will be measured. - Blood (about 1-2 teaspoons) and urine will be collected for routine tests. - You will have MRIs, CT scans, and/or x-rays to check the status of the disease. This is an investigational study. Zoledronic acid is FDA approved and commercially available for the treatment of breast cancer. Dasatinib is not FDA approved or commercially available for the treatment of breast cancer. It has been authorized for use in research only. Up to 28 patients will take part in this multicenter study. Up to 12 will be enrolled at MD Anderson.
Trial information was received from ClinicalTrials.gov and was last updated in December 2014.
Information provided to ClinicalTrials.gov by M.D. Anderson Cancer Center.