This trial is active, not recruiting.

Conditions breast cancer, cancer of the breast, breast neoplasm
Treatments letrozole (femara), letrozole; avastin
Phase phase 2
Sponsor University of Alabama at Birmingham
Collaborator Genentech, Inc.
Start date October 2007
End date September 2016
Trial size 75 participants
Trial identifier NCT00530868, F061229006, UAB 0648


This purpose of this trial is to show that the combination of Avastin and hormone therapy should be more effective than hormone therapy alone for the treatment of breast cancer.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment
letrozole; avastin Femara (Letrozole)
Letrozole 2.5 mg PO a day and Avastin 15 mg/kg IV every 3 weeks
letrozole (femara)
Letrozole 2.5 mg PO a day for 24 weeks

Primary Outcomes

Pathological complete response is defined as no evidence of residual invasive tumor in the breast or axillary lymph nodes or only residual ductal carcinoma in-situ.
time frame: 24 weeks

Secondary Outcomes

Clinical objective response; tolerability and toxicity; biomarkers for prognostic value.
time frame: 24 weeks

Eligibility Criteria

Male or female participants at least 19 years old.

Inclusion Criteria: All patients must meet the following criteria to be eligible for study entry: - Pathologically confirmed invasive ductal carcinoma or invasive lobular carcinoma of the breast, T2-T3 / T4a-c / N0-2 / M0, with positive estrogen and/or progesterone receptors, and Her-2-neu negative. Patients with inflammatory breast cancer will not be included (T4d). Patients previously treated patients with no measurable disease or patients with metastatic disease will be excluded. - Give written informed consent prior to study specific screening procedures, with the understanding that the patient has the right to withdraw from the study at any time, without prejudice. - Patients must be postmenopausal, defined as one of the following: - Patients > 50 years of age with no spontaneous menses for at least 12 months, - Bilateral oophorectomy - Be ambulatory (outpatient) and have an ECOG PS <1. - Patients must have measurable disease by mammogram and/or breast ultrasound (in special cases a dedicated breast MRI may be clinically indicated). The target lesion must not have been previously irradiated. - No prior chemotherapy. - Patients must have adequate organ and marrow function as defined as follows: absolute neutrophil count > 1,500/mm3, hemoglobin > 8.0 g/dl, platelets > 75,000/mm3, total bilirubin < 2 mg/dl, serum creatinine < 2 mg/dl, Transaminases (AST, ALT) may be up to 2 x institutional upper limit of normal. In addition < 1 gr of protein in 24 hr urine collection and urine protein/creatinine ratio < 1.0. - No life threatening parenchymal disease or rapidly progressing disease warranting cytotoxic chemotherapy. - Hypertension must be controlled (<150/100 mmHg). - Ejection Fraction > 50% by echocardiogram. (LVEF greater than 75% at baseline should be reviewed and/or the test repeated as it may be falsely elevated). - No history of thrombosis during the previous 12 months. Exclusion Criteria: - Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study other than this sponsor-investigator Bevacizumab cancer study. - Uncontrolled high blood pressure (>150/100 mmHg). - Unstable angina - New York Heart Association (NYHA) Grade III or greater congestive heart failure - History of myocardial infarction or unstable angina within 12 months - History of stroke or TIA within 12 months - Clinically significant peripheral vascular disease - History of a bleeding disorder - Presence of central nervous system or brain metastases - Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 0, anticipation of need for major surgical procedure during the course of the study - Minor surgical procedures (excluding fine needle aspirations or core biopsies) within 5 days prior to Day 0 - Pregnant (positive pregnancy test) or lactating - Urine protein: creatinine ratio greater than or equal to 1.0 at screening or patients demonstrating > 1 gr of protein in 24 hr urine collection within 4 weeks prior to study entry will not participate in the trial. - History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to Day 0 - Serious, non-healing wound, ulcer, or bone fracture - Unwilling or unable to comply with the protocol for the duration of the study. - Psychiatric illness/social situations that would limit compliance with study requirements. - History of another malignancy within the last five years except non-melanoma skin cancer and carcinoma in-situ of uterine cervix. - Patients with metastatic disease.

Additional Information

Official title A Phase II, Randomized, Open Label Trial of Pre-operative (Neoadjuvant)Letrozole (Femara) vs. Letrozole in Combination With Avastin in Post Menopausal Women With Newly Diagnosed Operable Breast Cancer
Principal investigator Andres Forero, M.D.
Description Preclinical and clinical data have demonstrated that up-regulation of tumor cell VEGF is an important mechanism to subvert estrogen dependence in hormone responsive breast cancer resulting in reduced therapy response or tumor resistance to hormonal therapy; thus, it is hypothesized that the combination of an anti-VEGF agent (Avastin, an anti-VEGF monoclonal antibody) and hormonal therapy should be more effective than hormonal therapy alone for the treatment of breast cancer.
Trial information was received from ClinicalTrials.gov and was last updated in February 2016.
Information provided to ClinicalTrials.gov by University of Alabama at Birmingham.