Overview

This trial is active, not recruiting.

Conditions schizophrenia, schizoaffective disorder, bipolar disorder, obesity, metabolic syndrome
Treatment olanzapine and melatonin
Sponsor Seattle Institute for Biomedical and Clinical Research
Collaborator Eli Lilly and Company
Start date July 2007
End date December 2016
Trial size 20 participants
Trial identifier NCT00512070, F1D-MC-X302

Summary

Atypical antipsychotic medications, such as olanzapine, cause metabolic side effects, including weight gain, extra fat around the middle of the body, high blood sugar, and high cholesterol. One of the mechanisms by which these medications may cause these effects is by reducing plasma melatonin. This study is a pilot project to evaluate 1) the effect of olanzapine on melatonin secretion levels and 2) the effect of melatonin on olanzapine-induced changes in melatonin secretion in patients with schizophrenia, schizoaffective, or bipolar disorder.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification safety/efficacy study
Intervention model parallel assignment
Masking double blind (subject, caregiver, investigator, outcomes assessor)
Primary purpose treatment
Arm
(Experimental)
0.3mg day melatonin
olanzapine and melatonin Olanzapine (Zyprexa)
In treatment phase I, all subjects will receive olanzapine, 10-25 mg/day. In treatment phase II, all subjects will receive olanzapine (10-25 mg/day) plus melatonin. Subjects will be randomized at a ratio of 1:1 to receive melatonin, 0.3 mg/day or 3.0 mg/day. Group IIA will receive 0.3mg day melatonin. Group IIB will receive 3.0 mg/day melatonin.
(Experimental)
3.0 mg/day melatonin
olanzapine and melatonin Olanzapine (Zyprexa)
In treatment phase I, all subjects will receive olanzapine, 10-25 mg/day. In treatment phase II, all subjects will receive olanzapine (10-25 mg/day) plus melatonin. Subjects will be randomized at a ratio of 1:1 to receive melatonin, 0.3 mg/day or 3.0 mg/day. Group IIA will receive 0.3mg day melatonin. Group IIB will receive 3.0 mg/day melatonin.

Primary Outcomes

Measure
Nocturnal melatonin production as estimated by assay of urinary 6-sulfatoxymelatonin (aMT6s) adjusted for creatinine
time frame: 6 and 12 weeks

Secondary Outcomes

Measure
Metabolic indices including weight, waist and hip measurements, and metabolic tests
time frame: 6 and 12 weeks

Eligibility Criteria

Male or female participants from 18 years up to 65 years old.

Inclusion Criteria: 1. Age 18-65; 2. DSM-IV-TR diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder; 3. Patients who, in the clinical judgment of the investigator, may benefit from a switch to olanzapine; 4. Females must be of non-child bearing potential (i.e., surgically sterilized, or at least one year post-menopausal) or on an appropriate dose of oral/depot contraceptives or using barrier protection and not breast-feeding. Females must have a urine pregnancy test at screening; 5. Willingness and ability to take medications nightly at 10:00 p.m.; and 6. The subject or his/her legal representative must provide informed, written consent. Exclusion Criteria: 1. Females who are pregnant or lactating; 2. Concurrent participation or participation within the prior 30 days in any study involving investigational medications; 3. Current (within the prior 30 days) diagnosis of substance abuse or dependence; 4. Use of olanzapine within the prior three months; 5. History of allergy or intolerable side-effects to olanzapine in the past; 6. History of significant head trauma, defined as head trauma resulting in loss of consciousness for more than five minutes and/or neurological or cognitive sequelae; 7. Evidence of any clinically relevant disease (e.g., renal or hepatic impairment, significant coronary artery disease, cerebrovascular disease, or cancer) or any clinical finding that in the opinion of the investigator could potentially be negatively affected by study participation or that could potentially affect study participation is criterion for exclusion from the study; 8. Use of fluvoxamine, nifedipine, or warfarin for 30 days prior to Baseline Visit.

Additional Information

Official title Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine and Melatonin Dose Finding for the Correction of the Metabolic Abnormality
Principal investigator Nael Kilzieh, M.D.
Description To investigate the relationship between olanzapine, melatonin, and metabolic functioning, this pilot study is evaluating 20 patients with schizophrenia, schizoaffective disorder, or bipolar disorder over 15 weeks under three experimental conditions: 1) baseline (two weeks treatment with already established antipsychotic medication other than olanzapine or clozapine), 2) six weeks treatment with olanzapine only, and 3) six weeks treatment with olanzapine and melatonin. Half of the patients will receive 0.3 mg of oral melatonin and half will receive 3.0 mg of melatonin. Nocturnal melatonin production, as estimated by assay of urinary 6-sulfatoxymelatonin(aMT6s) adjusted for creatinine, will be measured weekly. In addition, weekly measurements of weight and other metabolic indices, including waist and hip measurements, fasting glucose, serum insulin, cholesterol, triglycerides, and leptin will be taken. It is anticipated that there will be an olanzapine-induced decrease in melatonin production. Furthermore, it is expected that the decrease in melatonin production associated with olanzapine treatment will be reversed by administration of melatonin with olanzapine.
Trial information was received from ClinicalTrials.gov and was last updated in November 2015.
Information provided to ClinicalTrials.gov by Seattle Institute for Biomedical and Clinical Research.