Postconditioning in the Treatment of Acute ST-segment Elevation Myocardial Infarction
This trial is active, not recruiting.
|Condition||st-segment myocardial infarction|
|Treatments||standard primary pci, mechanical postconditioning|
|Start date||July 2007|
|End date||November 2008|
|Trial size||200 participants|
|Trial identifier||NCT00507156, KF 01 326257|
Standard treatment of patients with acute ST-segment elevation myocardial infarction consist of acute re-opening of the occluded coronary artery (primary PCI). Despite successful treatment of the epicardial vessel reperfusion is sometimes inadequate leading to large final infarct sizes. This phenomenon is known as the reperfusion injury. Several animal studies have indicated that graded re-opening of the artery may limit tissue damage. Generally this is referred to as mechanical postconditioning.
The study investigates the effect on final infarct size evaluated by magnetic resonance scan of postconditioning of ST-segment elevation myocardial infarctions. Mechanical postconditioning is performed by means of several balloon inflations in the injured vessel following its acute re-opening.
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
|Masking||single blind (subject)|
Final infarct size evaluated by MR
time frame: 3 month
MACE (death, re-infarction, TLR)
time frame: 1, 15 month
time frame: 15 month
Male or female participants at least 18 years old.
- Patients more than 18 years
- STEMI < 12 hours
- TIMI 0-1 in infarct related artery
- Multivessel disease (stenoses in non-infarct related arteries >70%)
- Cardiogenic shock
- Left main occlusions
- Lesions that cannot be treated with stents
- Previous CABG
- Severe renal insufficiency
- Previous extensive Q-wave infarction
|Official title||Postconditioning Used to Limit Final Infarct Size in Patients With Acute ST-segment Elevation Myocardial Infarction|
|Description||Please see above|
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