Overview

This trial is active, not recruiting.

Condition healthy
Treatments high fat diet, low fat diet
Sponsor Pennington Biomedical Research Center
Start date October 2010
End date July 2020
Trial size 65 participants
Trial identifier NCT00493701, PBRC 21041

Summary

This study is designed to predict weight gain overtime after a high fat diet.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Intervention model parallel assignment
Masking double blind (subject, investigator)
Primary purpose diagnostic
Arm
(Other)
Measurement of body weight in a fown with light undercloting (30 minutes) and height.
high fat diet Measurements will be collected to help with gathering data.
Daily eating
(Other)
Low-dose X0rays to determine the amount of fat, bone and muscle in your body.
low fat diet Questionnairs of food frequency
Life style eating habits

Primary Outcomes

Measure
Characterize the biochemical, endocrine, anthropometric and environmental characteristics of individuals with the "thrifty" phenotype.
time frame: 4 days of high fat diet

Secondary Outcomes

Measure
Identify the signaling pathways in skeletal muscle that are dysregulated in individuals with the "thrifty" phenotype through mRNA expression profiling in skeletal tissue.
time frame: 4 days after high fat diet

Eligibility Criteria

Male or female participants from 18 years up to 30 years old.

Inclusion Criteria: - Both genders and all races will be invited to participate - Women will be asked to participate in the follicular phase of the menstrual cycle as determined by menstrual history and a negative pregnancy test will be recorded prior to participation - BMI > 19 and < 35 - Age 18-30 Exclusion Criteria - Smokers - Unwilling or unable to abstain from alcohol consumption and caffeine consumption prior to testing and laboratory - Significant renal, hepatic, endocrine, pulmonary, cardiac or hematological disease - Pregnancy - Corticosteroid use in previous two months - Chronic use of anti-diabetic, anti-hypertensive, or other medications known to affect fat metabolism - Use of Depo-Provera, hormone implants or estrogen replacement therapy - Irregular menstrual cycles - Post-menopausal women - Weight gain or loss of > 3kg in the last 6 months For the MRI, the following exclusion criteria apply: - Individuals who have a heart pacemaker, defibrillator, or non-removable hearing aid - Individuals with any clips or metal plates in their head - Individuals who have any artificial limbs or prosthetic devices - Individuals who were ever injured by a metallic foreign body which was not removed - Individuals, who wear braces on their teeth, have non-removable false teeth, or removable bridgework

Additional Information

Official title ADAPT-The Adaptation to High Fat Diets
Principal investigator Steven R Smith, M.D.
Description In the past 3 years we have identified a "thrifty-phenotype" characterized in lean men by an inability to adapt rapidly to a high fat diet and associated with a low maximal VO2 and high fasting insulin. We hypothesize that the individuals with the "thrifty phenotype" are at higher risk for becoming obese, and that exercise may be effective in overcoming this problem. Several questions remain to be answered regarding the "thrifty" phenotype. First, given the large interindividual differences, how can we identify those at the highest risk? What are the distinguishing biochemical, endocrine and environmental characteristics of individuals that store fat when exposed to high fat diets? This is important because if these individuals can be easily identified, then dietary interventions can be targeted to this "at-risk" population. Second, what is different about the individual with the "thrifty phenotype"? Are there cellular pathways that are dysregulated in the skeletal muscle of these individuals when compared to controls? Is the defect intrinsic, i.e. a diminished ability to conserve glucose and oxidize fat in skeletal muscle or alternately, is the phenotype due to environmental, and dietary factors such as inactivity and energy excess? To answer these questions, we have planned a three-year project that aims to: - Characterize the biochemical, endocrine, anthropometric and environmental characteristics of individuals with the "thrifty" phenotype. - Identify the signaling pathways in skeletal muscle that are dysregulated in individuals with the "thrifty" phenotype through mRNA expression profiling in skeletal tissue. - Determine the role of environmental factors such as inactivity and caloric intake vs. intrinsic (genetic) factors in the "thrifty" phenotype.
Trial information was received from ClinicalTrials.gov and was last updated in January 2016.
Information provided to ClinicalTrials.gov by Pennington Biomedical Research Center.