This trial is active, not recruiting.

Condition infertility
Treatment human menopausal gonadotrophins
Sponsor University Hospital, Gasthuisberg
Start date January 2004
End date October 2013
Trial size 300 participants
Trial identifier NCT00492934, ML2436 - 30/12/2003


The study investigates if, among women with a regular cycle (between 25 and 45 days), the endometrium is better prepared for the transfer of an embryo that was cryopreserved and if the subsequent embryo implantation rate is higher when the cycle is started with daily, small-dose hormonal injections than in cycles without these daily injections.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment
(Active Comparator)
Daily injections with a small dose of gonadotrophins from day 2 of the cycle
human menopausal gonadotrophins Menopur
Daily subcutaneous injections, dose 37.5 IU or 75 IU, start on day 2 of the menstrual cycle until ovulation
(No Intervention)
No daily injections with hormones

Primary Outcomes

implantation rate per embryo
time frame: 15 days after the embryo transfer

Secondary Outcomes

thickness of the endometrium
time frame: 0-2 days before the human chorionic gonadotropin (hCG) injection

Eligibility Criteria

Female participants from 21 years up to 45 years old.

Inclusion Criteria: - Signed informed consent. - Women with a regular cycle (between 21 and 35 days). - Embryos with 50% intact blastomeres after thawing. - Embryo and endometrium are synchronized. Exclusion Criteria: - Embryo storage time not longer than 5 years.

Additional Information

Official title Natural Cycle Versus Stimulation With Human Menopausal Gonadotropin in Cycles With Cryopreserved Embryos
Trial information was received from ClinicalTrials.gov and was last updated in September 2014.
Information provided to ClinicalTrials.gov by University Hospital, Gasthuisberg.