This trial is active, not recruiting.

Condition age-related macular degeneration
Treatments ot-551, vehicle placebo
Phase phase 2
Sponsor Othera Pharmaceuticals
Start date June 2007
End date February 2010
Trial size 198 participants
Trial identifier NCT00485394, OT-551-C04


The purpose of this trial is to compare the ability of two doses of OT-551 ophthalmic solution and drug-free solution to safely and effectively treat geographic atrophy associated with age-related macular degeneration.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification safety/efficacy study
Intervention model parallel assignment
Masking double blind (subject, caregiver, investigator, outcomes assessor)
Primary purpose treatment
OT-551 0.3% ophthalmic solution
OT-551 0.3% ophthalmic solution, 2 drops 4 times daily
OT-551 0.45% ophthalmic solution
OT-551 0.45% ophthalmic solution, 2 drops 4 times daily
(Placebo Comparator)
vehicle placebo
vehicle placebo
OT-551 0% ophthalmic solution, 2 drops 4 times daily

Primary Outcomes

Change in the area of GA
time frame: 2 years

Eligibility Criteria

Male or female participants at least 55 years old.

Inclusion Criteria: - have a clinical diagnosis of GA in one or both eyes; - be of non-childbearing potential Exclusion Criteria: - have GA secondary to any condition other than AMD in the study eye; - have a BCVA of 20/200 or worse in the non-study eye; - have a history of or current choroidal neovascularization in either eye, or the need for any study eye anti-angiogenic therapy; - have any ocular condition in the study eye that would progress during the course of the study and could affect central vision or other ocular conditions that may be a confounding factor in this study; - need to wear contact lenses in the study eye during the study; - had confounding ocular surgery in the study eye; - have concomitant treatment with any systemic or ocular medication that is known to be toxic to the lens, retina, or optic nerve;

Additional Information

Official title A Randomized, Double-Masked, Dose-Ranging, Multi-Center, Phase II Study Comparing the Safety and Efficacy of OT-551 With Placebo to Treat Geographic Atrophy Associated With Age-Related Macular Degeneration
Description Age-related macular degeneration (AMD) results in severe, irreversible central vision loss and is the leading cause of blindness in individuals older than 50 years in the western world. The vast majority of AMD patients have the 'dry' (non-exudative) form that is characterized by the presence of drusen and atrophic changes in the retinal pigment epithelium (RPE). Dry AMD may remain static or progress slowly to produce areas of geographic atrophy (GA), the advanced or late-stage form of dry AMD. GA is a severe vision-threatening lesion of the macula that may impair visual function, impact daily life activities, and result in blindness. Currently, there is no approved treatment for dry AMD or GA. Pre-clinical results have shown that OT-551 may protect RPE cells and photoreceptors from oxidative damage and block angiogenesis stimulated by VEGF and other growth factors, and therefore is a therapeutic candidate for treating GA.
Trial information was received from ClinicalTrials.gov and was last updated in March 2008.
Information provided to ClinicalTrials.gov by Othera Pharmaceuticals.