Effect of Intranasal Administration of Orexine A on IL-6-System, Sleep-Wake-Regulation and Neurocognition
This trial is active, not recruiting.
|Sponsor||Zentrum für Integrative Psychiatrie|
|Start date||June 2007|
|End date||August 2009|
|Trial identifier||NCT00484757, DFG-SFB654/C5-Narkorex, Narkorex|
15 patients with narcolepsy and 15 healthy controls will be included in the study. According to a randomized, double-blind protocol they will receive intranasally at night first Orexine A and approximately two weeks later placebo or vice versa. Thereafter sleep will be recorded, the cytokine-system and neurocognition characterized.
|Intervention model||crossover assignment|
|Primary purpose||basic science|
Effect of orexine A on sleep, neurocognition and immune-system
Male or female participants at least 18 years old.
Inclusion Criteria: - Narcolepsy - Age >18 - Informed consent - GERMAN fluently spoken Exclusion Criteria: - Additional severe psychiatric or somatic disorders - Pregnancy or nursing - Anemia (Hb<10g/dl)
|Principal investigator||Dunja Hinze-Selch, MD|
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