Germline Mutations in Patients With Head and Neck Cancer and a Family History of Cancer
This trial is active, not recruiting.
|Condition||head and neck cancer|
|Treatments||gene expression analysis, mutation analysis, polymerase chain reaction, polymorphism analysis, flow cytometry, laboratory biomarker analysis|
|Sponsor||Vanderbilt-Ingram Cancer Center|
|Collaborator||National Cancer Institute (NCI)|
|Start date||March 2004|
|End date||December 2010|
|Trial size||400 participants|
|Trial identifier||NCT00482872, CDR0000546713, VICC-IRB-040030, VU-VICC-HN-0402|
RATIONALE: Studying gene mutations in samples of DNA from patients with head and neck cancer and a family history of cancer may help doctors learn more about the development of cancer in families.
PURPOSE: This clinical trial is studying germline mutations in patients with head and neck cancer and a family history of cancer.
|United States||No locations recruiting|
|Other Countries||No locations recruiting|
|Nashville, TN||Vanderbilt-Ingram Cancer Center - Cool Springs||no longer recruiting|
|Nashville, TN||Vanderbilt-Ingram Cancer Center at Franklin||no longer recruiting|
|Nashville, TN||Vanderbilt-Ingram Cancer Center||no longer recruiting|
Incidence of INK4a-p16 germline mutations
Biologic activity of identified INK4a-p16 germline mutations
Male or female participants at least 18 years old.
DISEASE CHARACTERISTICS: - Diagnosis of squamous cell carcinoma (SCC) of the head and neck - Must have ≥ 1 first-degree relative with any of the following cancers: - Non-small cell lung cancer - Melanoma - Pancreatic cancer - SCC of the head and neck - Lymphoma (controls) PATIENT CHARACTERISTICS: - Not specified PRIOR CONCURRENT THERAPY: - Not specified
|Official title||Familial HNSCC Syndrome and p16 Germline Mutations|
|Description||OBJECTIVES: - Measure the incidence of p16^INK4a germline mutations in patients with squamous cell carcinoma of the head and neck and a family history of cancer. - Determine biologic activity of identified p16^INK4a germline mutations. OUTLINE: DNA specimens are collected for genetic and mutation analysis and examined by PCR and flow cytometry. The activity of cells with p16 mutations is determined by cell cycle arrest functional assay.|
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