This trial is active, not recruiting.

Condition posttraumatic stress disorder
Treatment dialectical cognitive therapy
Phase phase 2
Sponsor Central Institute of Mental Health, Mannheim
Start date April 2007
End date December 2008
Trial size 64 participants
Trial identifier NCT00481000, PASA-0230


The purpose of this study is to determine whether Dialectical Cognitive Traumatherapy is effective in the treatment of severe and chronic Posttraumatic Stress Disorder (PTSD) following childhood sexual abuse.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment
(No Intervention)
Waitlist; Treatment as usual
dialectical cognitive therapy
Dialectical Behavior Therapy in Combination with Traumafocused CBT

Primary Outcomes

time frame: 1.5 years

Secondary Outcomes

general psychopathology
time frame: 1.5 years
change of pain threshold
time frame: 1.5 years
fMRI: activity of the amygdala
time frame: 6 months

Eligibility Criteria

Female participants at least 17 years old.

Inclusion Criteria: - Female - Minimum age of 17 - Childhood sexual abuse - Posttraumatic Stress Disorder (criteria of SCID) - At least one of the following diagnoses: Anorexia Nervosa, or Bulimia Nervosa, or substance abuse, or substance dependence, or major depression or at least 4 out of 9 criteria for Borderline Personality Disorder Exclusion Criteria: - Diagnosis of schizophrenia - Mental retardation - Body Mass Index lower than 16.5 - Acute delirium - Perilous selfharming behaviour during the last 4 month - Suicide attempt with the distinct intention to die during the last 4 month - Unstability (e.g. homelessness, acute victimisation by offender) - Pretreatment by DCT

Additional Information

Official title Dialectical Cognitive Traumatherapy (DCT) on Patients With Severe Posttraumatic Stress Disorder Following Sexual Abuse - A Randomised Controlled Trial
Principal investigator Anne S Dyer, PhD
Description Most studies on psychological treatments for PTSD exclude patients with severe, co-occurring psychopathology. We designed a new treatment (Dialectical Cognitive Trauma Therapy, or DCT) specifically to treat these patients. DCT includes elements of emotion regulation, mindfulness exercises, cognitive and exposure treatment, as well as new elements. This randomized controlled study evaluates the effect of inpatient DCT on these patients.
Trial information was received from ClinicalTrials.gov and was last updated in April 2010.
Information provided to ClinicalTrials.gov by Central Institute of Mental Health, Mannheim.