Overview

This trial is active, not recruiting.

Condition hemangioma, vascular anomalies
Treatments cheek cell samples or blood sample (4ml), cheek cell sample or blood sample (4ml)
Sponsor Medical College of Wisconsin
Collaborator Children's Hospital and Health System Foundation, Wisconsin
Start date April 2007
End date November 2014
Trial size 3000 participants
Trial identifier NCT00466375, Genetics of Hemangioma

Summary

The purpose of this study is to determine if there are genes that are common in children with infantile hemangioma. This information will allow physicians to improve care for patients who have been diagnosed with this disease and to provide their parents with more complete information regarding the cause of this disease. This research is being done because many unanswered questions remain regarding children with infantile hemangioma. There are very few medications to treat infants with hemangiomas.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model family-based
Arm
Patients with a hemangioma.
cheek cell samples or blood sample (4ml)
DNA will be extracted from cheek cell or blood samples from parents and child having hemangioma.
Patients with a vascular anomaly.
cheek cell sample or blood sample (4ml)
DNA will be extracted from cheek cell or blood samples of parents and child with a vascular anomaly.

Primary Outcomes

Measure
SNP
time frame: 3 years

Eligibility Criteria

Male or female participants of any age.

Study Population Inclusion Criteria: - No limit to age - Diagnosis of infantile hemangioma and/or vascular anomaly - Unaffected twin sibling - Each patient's authorized legal guardian must understand the nature of the study and must provide written informed consent. Each patient must also give assent to study participation. Study Population Exclusion Criteria: - Diagnosis other than infantile hemangioma or vascular anomaly - If the lesion has resolved and cannot be confirmed as a hemangioma by clinical exam - If the biologic parents are unwilling or unable to submit DNA samples the child will be excluded from the DNA study. Therefore, if DNA samples cannot be or are not obtained from both biologic parents, the child and family will be excluded from the study.

Additional Information

Official title Genetic Basis of Hemangiomas
Principal investigator Beth Drolet, MD
Description WHAT IS INVOLVED IN THE RESEARCH STUDY? - Buccal smear (cheek cells) or small blood sample (4 mL or 1 teaspoon) from child being seen in the Dermatology clinic having infantile hemangioma or vascular anomaly - Buccal smear (cheek cells) or small blood sample (4 mL or 1 teaspoon) from parents of child If you and your child agree to be in this study, the following will happen: 1. Informed consent and permission to use or disclose your/your child's health information for research purposes will be obtained by Dr. Drolet, the principal investigator, or her research team. You will receive a copy of this consent form. 2. A buccal swab or blood sample will be obtained from you and your child; buccal sampling involves rubbing the inside of your cheek and removing cells to perform a genetic test called "Genomewide Association (GWA). We expect you and your child to be involved in this study until you and your child have the genetic testing performed.
Trial information was received from ClinicalTrials.gov and was last updated in March 2016.
Information provided to ClinicalTrials.gov by Medical College of Wisconsin.