Overview

This trial is active, not recruiting.

Conditions copd, hyperglycemia
Treatments tight insulin treatment in patients hospitalized with copd exacerbation, tight glycemic control
Sponsor Soroka University Medical Center
Start date April 2007
End date May 2010
Trial size 84 participants
Trial identifier NCT00452296, sor450807ctil

Summary

Glucose control has been shown as an important and independent prognostic factor in several acute conditions in hospitalized patients, including Acute MI, stroke, cardiac surgery and in critical care units.

Patients with acute exacerbation of COPD (AECOPD)and diabetes treated with insulin had a longer in-patient stay and more frequent isolation of Gram negative bacteria from sputum than those without diabetes.Hyperglycemia (>11 mmol/l) on admission predicted failure of non-invasive ventilation and infectious pulmonary complications in patients admitted to the ICU with acute respiratory failure caused by severe AECOPD.

The primary goal of this study is to test the hypothesis that in AECOPD, tight glycemic control during hospital stay will improve outcome of hospitalization.

The secondary goal of this study is to test new ways in controlling patients in the internal medicine ward.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Intervention model single group assignment
Masking open label
Primary purpose diagnostic

Primary Outcomes

Measure
mortality
time frame: one year

Secondary Outcomes

Measure
hospialization
time frame: one year

Eligibility Criteria

Male or female participants from 45 years up to 90 years old.

Inclusion Criteria: - current or past smokers (at least 20 py) - patient with COPD be ATS criteria - hospitalized with acute exacerbation, 2/3 criteria:1- worsening of SOB 2-change in sputum volume 3- change in sputum color - signed informed concent Exclusion Criteria: - respiratory failure (pH<7.35 ו Pco2>60 ) - pneumonia - pneumothorax - bronchiectasis - lung collapse - congestive heart failure - lung cancer - suspected pulmonary emboli - immune deficiency (acquired 0r congenital) - cystic fibrosis - post lung implantation - asthma/ non smokers

Additional Information

Official title Tight Glycemic Control in Acute Exacerbations of COPD
Principal investigator Idit F Liberty
Trial information was received from ClinicalTrials.gov and was last updated in June 2012.
Information provided to ClinicalTrials.gov by Soroka University Medical Center.