This trial is active, not recruiting.

Conditions childhood acute lymphoblastic leukemia in remission, childhood acute myeloid leukemia in remission, childhood chronic myelogenous leukemia, childhood myelodysplastic syndromes, chronic phase chronic myelogenous leukemia, de novo myelodysplastic syndromes, juvenile myelomonocytic leukemia, previously treated myelodysplastic syndromes, recurrent childhood acute lymphoblastic leukemia, secondary myelodysplastic syndromes
Treatments allogeneic bone marrow transplantation, laboratory biomarker analysis, filgrastim
Phase phase 3
Sponsor Children's Oncology Group
Collaborator National Cancer Institute (NCI)
Start date December 2007
End date June 2013
Trial size 27 participants
Trial identifier NCT00450450, ASCT0631, CDR0000532926, COG-ASCT0631, COG-PBMTC-STC051, NCI-2009-01069, U10CA098543


This randomized phase III trial is studying donor bone marrow transplant with or without G-CSF to compare how well they work in treating young patients with hematologic cancer or other diseases. Giving chemotherapy and total-body irradiation before a donor bone marrow transplant helps stop the growth of cancer or abnormal cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving methotrexate and tacrolimus or cyclosporine before and after transplant may stop this from happening. It is not yet known whether donor bone marrow transplant is more effective with or without G-CSF in treating hematologic cancer or other diseases.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment
Patients undergo filgrastim (G-CSF)-stimulated allogeneic bone marrow transplantation on day 0.
allogeneic bone marrow transplantation bone marrow therapy, allogeneic
Patients undergo allogeneic BMT
laboratory biomarker analysis
Correlative studies
filgrastim Granulocyte Colony-Stimulating Factor
Given IV
(Active Comparator)
Patients undergo conventional allogeneic bone marrow transplantation on day 0.
allogeneic bone marrow transplantation bone marrow therapy, allogeneic
Patients undergo allogeneic BMT
laboratory biomarker analysis
Correlative studies

Primary Outcomes

Event-free survival
time frame: 2 years

Secondary Outcomes

Graft failure rate
time frame: Up to 10 years
Incidence of grade III-IV acute graft-versus-host disease
time frame: Up to 3 months
Treatment-related mortality
time frame: Day 100
Incidence of chronic graft-versus-host disease
time frame: 18 months post-transplant
Time to neutrophil engraftment
time frame: Up to 10 years
Median length of initial hospitalization
time frame: Up to 10 years
Immune reconstitution
time frame: Up to 1 year
Infused nucleated and CD34+ cell doses
time frame: Up to 10 years

Eligibility Criteria

Male or female participants up to 21 years old.

Inclusion Criteria: - Diagnosis of hematologic cancer or other disease, including any of the following: - Chronic myelogenous leukemia in first or second chronic phase - Acute lymphoblastic leukemia (ALL), meeting any of the following criteria: - Relapsed ALL enrolled on a Children's Oncology Group (COG) relapse clinical trial OR received ≥ 1 round of reinduction therapy (4-6 weeks) and 1 round of intensive consolidation chemotherapy (3-6 weeks) - ALL in second complete remission (CR)* after a bone marrow, extramedullary, or combined bone marrow and extramedullary relapse - Very high-risk ALL in first CR, defined as any of the following: - Philadelphia chromosome-positive ALL - Hypodiploidy (< 44 chromosomes) - Mixed lineage leukemia rearrangement - Induction failure - Acute myeloid leukemia in first or second CR - Induction therapy must be completed - Juvenile myelomonocytic leukemia - Myelodysplastic syndromes - No clinically evident CNS or extramedullary disease - No blasts seen on cerebrospinal fluid cytospin - Post-relapse reinduction therapy must be completed - Not planning to receive reduced-intensity conditioning regimen - Not planning to receive a graft that has undergone T-cell depletion - No Down syndrome - Matched sibling donor must be available and must be enrolled on ASCT0631D companion study - Karnofsky performance status (PS) 60-100% (patients > 16 years of age) OR Lansky PS 60-100% (patients ≤ 16 years of age) - AST or ALT < 5 times upper limit of normal for age - Bilirubin < 2.5 mg/dL (unless due to Gilbert's syndrome) - Creatinine clearance or radioisotope glomerular filtration rate ≥ 70 mL/min OR serum creatinine base on age and/or gender as follows: - 0.4 mg/dL (1 month to < 6 months of age) - 0.5 mg/dL (6 months to < 1 year of age) - 0.6 mg/dL (1 to 2 years of age) - 0.8 mg/dL (2 to < 6 years of age) - 1.0 mg/dL (6 to < 10 years of age) - 1.2 mg/dL (10 to < 13 years of age) - 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to < 16 years of age) - 1.7 mg/dL (male) or 1.4 mg/dL (female) (≥ 16 years of age) - Shortening fraction ≥ 27% by echocardiogram OR LVEF ≥ 50% by radionuclide angiogram - FEV_1, FVC, and DLCO ≥ 60% OR meets the following criteria (for patients unable to cooperate for pulmonary function tests): - No evidence of dyspnea at rest - No exercise intolerance - No requirement for supplemental oxygen therapy - Not pregnant or nursing - No known HIV - No known uncontrolled fungal, bacterial, or viral infections - Patients acquiring fungal disease during induction therapy may proceed if they have a significant response to antifungal therapy with no or minimal evidence of disease remaining by CT scan - No prior allogeneic or autologous stem cell transplantation

Additional Information

Official title A Phase III Randomized Trial of G-CSF Stimulated Bone Marrow vs. Conventional Bone Marrow as a Stem Cell Source In Matched Sibling Donor Transplantation
Principal investigator Stephan A. Grupp, MD PhD
Description PRIMARY OBJECTIVE: I. Compare improvement in event-free survival of patients with hematologic cancer or other diseases undergoing filgrastim (G-CSF)-stimulated bone marrow transplantation (BMT) vs conventional BMT. SECONDARY OBJECTIVES: I. Compare the incidence and time to engraftment in patients treated with these regimens. II. Compare rates of acute and chronic graft-vs-host disease (GVHD) in patients treated with these regimens. III. Correlate incidence of acute and chronic GVHD with absolute T-cell numbers, Th1 vs Th2 profile of T cells, dendritic cell populations, and T-regulatory cell content. IV. Assess the impact of G-CSF-stimulated BMT as a stem cell source on hospital stay and treatment-related mortality at day 100 in patients treated with this regimen. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to risk (high vs intermediate vs standard). CONDITIONING REGIMEN: Co-enrolled on COG-ASCT0431 or COG-AAML0531; Patients receive a conditioning regimen as defined on that treatment study. ACUTE LYMPHOBLASTIC LEUKEMIA (ALL): Patients undergo total-body irradiation (TBI) twice daily on days -8 to -6. Patients receive thiotepa IV on days -5 and -4 and high-dose cyclophosphamide IV over 1 hour on days -3 and -2. Some patients with CNS leukemia or very high-risk ALL in first complete remission receive cranial radiotherapy. ACUTE MYELOID LEUKEMIA, JUVENILE MYELOMONOCYTIC, CHRONIC MYELOGENOUS LEUKEMIA, OR MYELODYSPLASTIC SYNDROMES: (myeloid malignancies) Patients receive busulfan IV over 2 hours every 6 hours on days -9 to -6 and high-dose cyclophosphamide IV over 1 hour on days -5 to -2. GRAFT-VS-HOST DISEASE (GVHD) PROPHYLAXIS: Co-enrolled on COG-ASCT0431 or COG-AAML0531: Patients undergo GVHD prophylaxis as defined on that treatment study. ALL: Patients receive tacrolimus IV or orally beginning on day -2 and continuing until day 42, followed by a taper until day 98. Patients also receive methotrexate IV on days 1, 3, and 6. MYELOID MALIGNANCIES: Patients receive cyclosporine IV continuously or orally beginning on day -1 and continuing until day 42 or day 50, followed by a taper for 8-16 weeks. Patients also receive methotrexate IV on days 1, 3, 6, and 11. ALLOGENEIC BONE MARROW TRANSPLANTATION (BMT): Patients are randomized to 1 of 2 transplantation arms. ARM I: Patients undergo filgrastim (G-CSF) -stimulated allogeneic BMT on day 0. ARM II: Patients undergo conventional allogeneic BMT on day 0. After completion of study treatment, patients are followed at 1 year and then annually for 5-10 years.
Trial information was received from ClinicalTrials.gov and was last updated in March 2016.
Information provided to ClinicalTrials.gov by Children's Oncology Group.