Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques
This trial is active, not recruiting.
|Conditions||atherosclerosis, aortic aneurysm, peripheral vascular diseases|
|Sponsor||Sheba Medical Center|
|Collaborator||University Hospital Goettingen|
|Start date||March 2001|
|End date||July 2015|
|Trial size||120 participants|
|Trial identifier||NCT00449306, SHEBA-01-2354-JS-CTIL|
Lipid-rich atherosclerotic plaques, or "vulnerable plaques" are prone to rupture, causing local intravascular thrombosis, with subsequent grave clinical consequences. Atherosclerotic plaques normally removed during surgery, and peripheral blood samples will be studied to achieve the following objectives:
"1" Define histological features of the vulnerable plaque, analyze its physical characteristics, and investigate selected gene expression.
"2" Study biomarkers of inflammation in conjunction with the presence of vulnerable plaques.
"3" Explore the potential role of infection in atherogenesis.
|Observational model||case control|
To uncover mechanisms of cardiovascular diseases
time frame: 3 years
Male or female participants at least 18 years old.
Inclusion Criteria: - Evidence of symptomatic carotid stenosis exceeding 60%(TIAs or stroke within the last 6 months), and asymptomatic carotid artery stenosis (presenting with progressive carotid stenosis, exceeding 70%) - Abdominal aortic aneurysm, and aortic occlusive disease - Peripheral occlusive or aneurysmal disease Exclusion Criteria: - Non-compliant patients, incapable of granting approval by informed consent
|Official title||Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques|
|Principal investigator||Jacob Schneiderman, MD|
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