Resistance Rates and Mechanisms of Resistance to Imipenem and Meropenem at UPMC
This trial is active, not recruiting.
|Condition||gram negative organism|
|Sponsor||University of Pittsburgh|
|Start date||February 2007|
|End date||December 2016|
|Trial size||1000 participants|
|Trial identifier||NCT00443885, PRO07020078|
The isolate samples will be collected over a period of one year once IRB approval has been obtained. These isolates were collected as part of the patient's clinical care and once all clinical testing is complete, all isolates will be discarded. The honest broker of our area will collect the isolates and deidentify all information once all clinical testing is complete. The isolates will be obtained from the microbiology lab.
dead or alive
time frame: end of study
Male or female participants of any age.
Inclusion Criteria: - Samples" for the purpose of this study are Gram negative bacteria in a Petri dish of growth media.
|Official title||Resistance Rates and Mechanisms of Resistance to Imipenem and Meropenem at UPMC to Problematic Gram-negative Organisms|
|Principal investigator||Brian Potoski, Pharm D|
|Description||The study will collect two hundred pseudomonas and 20 acinetobacter baumanti consecutive bacterial isolates from microbiology. These isolates are collected as part of the patient's clinical care and are discarded once all clinical testing is complete. The honest broker will obtain these samples after all clinical testing is complete. All isolates will be deidentified. These isolates will be tested using standardized susceptibility methods for meropenem and imipenem. The activity of doripenem, a carbapenem currently being studied, and arbekacin an aminoglycoside, will also be tested. The honest broker will also collect limited patient data including underlying condition, presence of a solid organ transplant, ward location, and antibiotic history over the three months prior to organism isolation. For resistant isolates found, analytical and molecular techniques will be performed to determine the mechanisms of resistance and whether resistant isolates are coming from a single source/being transmitted from person to person.|
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