Overview

This trial is active, not recruiting.

Conditions cardiovascular diseases, metabolic syndrome
Treatment intake of rainbow trout from different feeding conditions versus a control poultry meal
Sponsor University of Copenhagen
Collaborator Danish Institute of Fisheries Research, Denmark
Start date January 2007
End date March 2007
Trial size 6 participants
Trial identifier NCT00432952, M186

Summary

The acute effects of farmed rainbow trout, fed by various feeds versus a control meal with poultry meat on cardiovascular risk markers and plasma protein expression are investigated.

The hypotheses of the study are that if the feed are changed from a marine origin to primarily a vegetable origin the content of long chain n-3 poly unsaturated fatty acids (n-3 PUFA) will decrease in the meat and thus possibly result in a decreased effect on health. Furthermore, the feed of the trouts are also expected to give rise to differences in the human plasma protein profile and fatty acid composition after consumption, which could be associated with physiological effects.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification bio-availability study
Intervention model crossover assignment
Masking single blind
Primary purpose prevention

Primary Outcomes

Measure
plasma protein expression
time frame:
Blood Pressure
time frame:
Pulse Wave Analysis
time frame:
Pulse wave Velocity
time frame:

Secondary Outcomes

Measure
Plasma Triglycerides
time frame:

Eligibility Criteria

Male participants from 40 years up to 70 years old.

Inclusion Criteria: - Non regular smokers - Body Mass Index (18.5-30 kg/m2) - Able to eat fish Exclusion Criteria: - Exercise >10 h/week - Chronical diseases (eg. cardiovascular and diabetes) - Regular medication - Fish oil supplementation - Blood donation 2 month prior or during participation - Above maximum recommended alcohol intake - Blood pressure >160/100 mm Hg

Additional Information

Principal investigator Lotte Lauritzen, Ph.D
Description In a controlled, single blinded human single meal study the acute effects of farmed rainbow trout, fed by various feeds versus a control meal with poultry meat on cardiovascular risk markers and plasma protein expression are investigated. 6 healthy men, age 40-70, will be randomized to trout fed on only vegetable, only marine and a mix of different compositions of vegetable and marine feeds. Outcome variables are blood pressure, pulse wave analyse, pulse wave velocity, plasma protein profile, and plasma triglycerides. The hypotheses of the study are that if the feed are changed from a marine origin to primarily a vegetable origin the content of long chain n-3 poly unsaturated fatty acids (n-3 PUFA) will decrease in the meat and thus possibly result in a decreased effect on health. Furthermore, the feed of the trouts are also expected to give rise to differences in the human plasma protein profile and fatty acid composition after consumption, which could be associated with physiological effects.
Trial information was received from ClinicalTrials.gov and was last updated in August 2008.
Information provided to ClinicalTrials.gov by University of Copenhagen.