This trial is active, not recruiting.

Condition gram-negative bacterial infections
Sponsor University of Pittsburgh
Collaborator Merck Sharp & Dohme Corp.
Start date December 2006
End date December 2016
Trial size 100 participants
Trial identifier NCT00394784, IRB#0608120


This research is important because it allows for the determination of resistance rates to antibiotics that may not be frequently tested by the clinical microbiology laboratory at University of Pittsburgh Medical Center (UPMC)-Presbyterian. It also will provide antibiotic minimum inhibitory concentrations (MICs) for these pathogens which may help in identifying the best empiric antibiotic option for gram-negative blood stream infections based on known pharmacodynamic parameters.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Time perspective retrospective

Primary Outcomes

dead or alive
time frame: end of study

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Patients with positive gram-negative bacteria Exclusion Criteria: - Less than 18 years of age

Additional Information

Official title Surveillance Study - Incidence of Antibiotic Resistance in Serial Gram-negative Bloodstream Isolates
Principal investigator Brian Potoski, PharmD
Description Bacterial cultures will be ordered in the normal clinical course of the management of patients in the liver transplant ICU by the medical team. These cultures are then processed by the clinical Microbiology laboratory in the normal manner. If these cultures grow a Gram-negative bacteria, they are eligible for this study. Typically the clinical Microbiology laboratory saves these bacteria for a period of time after the final microbiology report. At this time, unless asked otherwise, the bacteria will be placed in biohazardous waste containers for proper disposal. If these cultures have grown a Gram-negative bacteria, they are eligible for this study, and will not be disposed of but will be given to the investigators without identifiers for this study. The antibiotic susceptibility of these organisms will be tested by the investigators in a separate research laboratory. Mechanisms of antibiotic resistance may also be assessed.
Trial information was received from ClinicalTrials.gov and was last updated in December 2015.
Information provided to ClinicalTrials.gov by University of Pittsburgh.