This trial is active, not recruiting.

Condition hiv infections
Sponsor National Institute of Allergy and Infectious Diseases (NIAID)
Collaborator Community Programs for Clinical Research on AIDS
Trial size 3261 participants
Trial identifier NCT00377169, CPCRA 065H, SMART


The purpose of this study is to collect blood samples from SMART study participants to use in future genetic studies.

United States No locations recruiting
Other countries No locations recruiting

Eligibility Criteria

Male or female participants at least 13 years old.

Inclusion Criteria: - Coenrollment in the SMART study - Parent or guardian willing to provide informed consent, if applicable

Additional Information

Official title Genomics: A Substudy of a Large, Simple Trial Comparing Two Strategies for Management of Anti-Retroviral Therapy (The SMART Study)
Description Despite progress in the treatment of HIV and a greater understanding of the pathophysiology of HIV infection, there are still unexplained differences in both the progression of untreated HIV infection and response to antiretroviral therapy. These differences are likely related to the unique genetic makeup of individuals with HIV infection. Particular genes may offer protection against HIV infection, while other genes may make disease progression more likely. Knowing more about the genetic makeup of HIV infected individuals may lead to the development of a targeted treatment strategy based on an individual's specific risk of disease progression and sensitivity to medication toxicity. The purpose of this substudy is to collect blood samples from SMART study participants. The samples will be used in future Community Programs for Clinical Research on AIDS (CPCRA) studies investigating the link between human genetic factors and clinical outcome data. This study will enroll individuals currently participating in the SMART study. Participants will provide one blood sample. Individual test results from future blood analyses will not be provided to a patient unless they may have profound health implications for that patient.
Trial information was received from ClinicalTrials.gov and was last updated in November 2007.
Information provided to ClinicalTrials.gov by National Institute of Allergy and Infectious Diseases (NIAID).