Overview

This trial is active, not recruiting.

Condition resistant cystoid macular edema
Treatments intravitreal injection of triamcinolone, intravitreal injection of avastin
Phase phase 1
Sponsor Shahid Beheshti Medical University
Start date August 2006
End date May 2008
Trial size 40 participants
Trial identifier NCT00371111, 8524

Summary

Cystoid macular edema (CME) is one of the common causes of vision loss in patients with UveitiS .Triamcinolone has been effectively used in reducing CME and improving the vision. Also there are some documents which recommend Bevacizumab(avastin) could reduce macular edema. This study compare intravitreous injection of triamcinolone and avastin in patients with resistant uveitic cystoid macular edema.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification safety/efficacy study
Intervention model parallel assignment
Masking single blind (subject)
Primary purpose treatment
Arm
(Active Comparator)
Intravitreal injection of Triamcinolone
intravitreal injection of triamcinolone
4 mg of Triamcinolone
(Active Comparator)
Intravitreal injection of Avastin
intravitreal injection of avastin
Injection of 1.25 mg of Avastin and

Primary Outcomes

Measure
Resorbed CME in OCT
time frame: every 3 month
Resorbed CME in clinical examination
time frame: Every 3 month

Secondary Outcomes

Measure
need to retreatment
time frame: when ever needed

Eligibility Criteria

Male or female participants of any age.

Inclusion Criteria: - Uveitic CME - Uveitic CME refractory to routine treatment - Vision better than 5/200 and worse than 20/50 Exclusion Criteria: - Mono- Ocular patients - History of vitrectomy - Glaucoma or ocular hypertension - History of other retinal disease that can cause macular edema - Pregnancy - Significant media opacity - Vision better than 20/50

Additional Information

Principal investigator Masoud Soheilian, MD
Description This study compare intravitreous injection of triamcinolone and avastin in patients with resistant uveitic cystoid macular edema.
Trial information was received from ClinicalTrials.gov and was last updated in July 2008.
Information provided to ClinicalTrials.gov by Shahid Beheshti Medical University.