This trial is active, not recruiting.

Condition brain and central nervous system tumors
Treatments cisplatin, temozolomide, fluorescence in situ hybridization, loss of heterozygosity analysis, immunohistochemistry staining method, laboratory biomarker analysis, radiation therapy
Phase phase 2
Sponsor Children's Cancer and Leukaemia Group
Start date April 2004
Trial size 87 participants
Trial identifier NCT00360945, CCLG-CNS-2004-02, CDR0000482280, EU-20622


RATIONALE: Drugs used in chemotherapy, such as cisplatin and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving cisplatin together with temozolomide works in treating young patients with malignant glioma.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation non-randomized
Masking open label
Primary purpose treatment

Primary Outcomes

Response rate after 2 courses
time frame:

Secondary Outcomes

Relapse-free survival
time frame:
Best response in patients receiving more than 2 courses
time frame:
Rate of progression at 6 months and 1 and 2 years
time frame:
Overall survival
time frame:

Eligibility Criteria

Male or female participants from 4 years up to 20 years old.

DISEASE CHARACTERISTICS: - Histologically or cytologically confirmed diagnosis of 1 of the following grade III or grade IV malignant glial tumors*: - Glioblastoma - Anaplastic astrocytoma - Anaplastic oligodendroglioma - Anaplastic oligoastrocytoma - Anaplastic ganglioglioma - Anaplastic mixed tumor - Glial component is essential NOTE: *Malignant gliomas occurring as a second primary malignancy allowed - Newly diagnosed or recurrent disease - No malignant brain stem tumors - Incompletely resected tumors - No completely resected tumors - Measurable or evaluable disease by conventional MRI PATIENT CHARACTERISTICS: - Lansky performance status 40-100% - Organ toxicity ≤ grade 2 - Absolute neutrophil count ≥ 1,000/mm³ - Platelet count ≥ 100,000/mm³ - Bilirubin ≤ 1.5 times upper limit of normal (ULN) - AST and ALT ≤ 2.5 times ULN - Prothrombin ≥ 50% - Fibrinogen ≥ 1.5 g/L - Creatinine normal for age - Creatinine ≤ 65 µmol/L (4-15 years of age) - Creatinine ≤ 110 µmol/L (15-20 years of age) - Audiogram with toxicity grade ≤ 2 - ECG normal - Negative pregnancy test - Fertile patients must use effective contraception - No severe or life-threatening infection - No uncontrolled developing or symptomatic intracranial hypertension PRIOR CONCURRENT THERAPY: - At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas) or radiotherapy for patients with relapsed disease - No prior cisplatin or temozolomide - No other concurrent anticancer therapy

Additional Information

Official title Phase II Study of the Combination of Cisplatin + Temozolomide in Malignant Glial Tumours in Children and Adolescents at Diagnosis or in Relapse
Description OBJECTIVES: Primary - Determine the objective response rate (complete and partial response) in pediatric patients with malignant gliomas treated with temozolomide and cisplatin. Secondary - Identify genetic, metabolic, and proteomic profiles that will provide an insight into the molecular pathways involved in the pathogenesis of these tumors. - Link genetic changes with clinical details, histopathology, and patient outcome, thereby developing a biological basis for diagnosis, prognosis, and treatment monitoring. - Evaluate relapse-free survival at 1 and 2 years in patients treated at diagnosis. - Evaluate the duration of clinical response in patients treated at relapse. - Study the health status and quality of life of these patients. - Evaluate long-term toxicity of this therapeutic combination. - Evaluate the ability of magnetic resonance spectroscopy vs CT scan to predict response in patients with high-grade astrocytomas. OUTLINE: This is a multicenter, open-label, nonrandomized, parallel-group study. Patients are stratified according to disease status (newly diagnosed vs relapsed). Patients with newly diagnosed disease are further stratified according to spread of disease (localized and measurable vs diffuse unmeasurable). - Stratum I (newly diagnosed disease): Patients receive CISTEM chemotherapy comprising cisplatin IV over 3 hours on day 1 and oral temozolomide once daily on days 2-6. Treatment repeats every 28 days for up to 7 courses. Patients who achieve responsive or stable disease after 2 courses receive 2 more courses of CISTEM chemotherapy and then undergo radiotherapy 5 days a week for 6 weeks. After completion of radiotherapy, patients may receive up to 3 more courses of CISTEM chemotherapy for a total of 7 courses. - Stratum II (relapsed disease): Patients receive CISTEM chemotherapy for up to 7 courses as in stratum I. Patients who reach the maximum dose allowed for cisplatin may receive oral temozolomide alone indefinitely. Tissue and blood samples are obtained at baseline and examined by immunohistochemistry, fluorescent in situ hybridization (FISH), and loss of heterozygosity. The tumor tissue is analyzed for p53, MSH2, MLH1, and MGMT. After completion of study treatment, patients are followed periodically for 2 years. PROJECTED ACCRUAL: A total of 87 patients will be accrued for this study.
Trial information was received from ClinicalTrials.gov and was last updated in September 2013.
Information provided to ClinicalTrials.gov by National Cancer Institute (NCI).