Does a Migraine Medication Decrease Rotational Motion Sickness in People Suffering From Migraines?
This trial is active, not recruiting.
|Sponsor||University of Pittsburgh|
|Collaborator||Merck Sharp & Dohme Corp.|
|Start date||August 2006|
|End date||January 2009|
|Trial size||25 participants|
|Trial identifier||NCT00360282, 0602009, Merck31449|
The purpose of this study is to determine if Rizatriptan, a migraine medication, lowers motion sickness in migraine sufferers.
|Endpoint classification||efficacy study|
|Intervention model||crossover assignment|
|Masking||double blind (subject, investigator)|
Motion Sickness Scores
time frame: Prospective
Male or female participants from 21 years up to 45 years old.
Inclusion Criteria: - History of motion sickness - Currently suffering from migraines with at least 2 episodes during the previous 12 months - Previous use and tolerance to triptans Exclusion Criteria: - Current tobacco user - History of or current hypertension, cardiac disease, arrhythmia, hypercholesterolemia, hemiplegic/basilar migraine, stroke, diabetes, vascular disease or kidney disease - Family history of early myocardial infarction (first-degree relative < 45 years old at time of event) - Constant dizziness or constant vestibular symptoms - History of ear, nose and throat (ENT) disease, e.g. Meniere's disease - Current treatment with propranolol or medications that would preclude use of a triptan(e.g. ergotamine) - Major vestibular abnormality found on screening - Testing positive on over-the-counter pregnancy test - Taken an Monamine Oxidase (MAO) inhibitor within two weeks of testing - Allergy or intolerance to gelatin - Corrected visual acuity of > 20/40 O.U. - Women who are pregnant or breastfeeding
|Official title||Effect of Rizatriptan on Rotational Motion Sickness in Migraineurs|
|Principal investigator||Joseph M Furman, MD, PhD|
|Description||Migraine sufferers undergo vestibular tests to note abnormalities. There are 2 experimental visits in which migraine sufferers are given either the Rizatriptan or a fake pill and then are asked to rotate in a chair that is tilted. Motion sickness scores are taken throughout testing.|
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