Overview

This trial is active, not recruiting.

Conditions choroidal neovascularisation, polypoidal choroidal vasculopathy
Treatment bevacizumab (tradename: avastin)
Phase phase 3
Sponsor Singapore National Eye Centre
Start date June 2006
End date May 2008
Trial size 50 participants
Trial identifier NCT00344617, R452/01/2006

Summary

To assess the use of Avastin for the management of serosanguinous maculopathy

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation non-randomized
Endpoint classification safety/efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment

Primary Outcomes

Measure
Change from baseline in VA, i.e. gain or loss of 5 letters (1 line), 15 letters (3 lines) or 30 letters (6 lines)
time frame:

Secondary Outcomes

Measure
Change in OCT measured central retinal thickness
time frame:
Correlation in change in central retinal thickness and change in VA
time frame:

Eligibility Criteria

Male or female participants at least 50 years old.

Inclusion Criteria: 1. All subfoveal/juxtafoveal CNV and PCV (polypoidal choroidal vasculopathy) who are not eligible for other treatment options (compassionate use) 2. CNV and PCV lesions which have failed PDT, conventional argon laser photocoagulation (salvage use) 3. CNV and PCV lesions treatable with PDT, but cannot afford or refused Exclusion Criteria: 1. Patients with uncontrolled hypertension (systolic BP greater than 150mmHg or diastolic BP greater than 90mmHg 2. History of thrombolic events such as myocardial infarction or cerebral vascular accident 3. Renal abnormalities (as defined by established history of chronic renal disease or renal failure as well as patients requiring dialysis). 4. Recent (as defined as the past 28 days) or planned (as defined as the next 3 months) surgery. 5. Coagulation abnormalities, including anti-coagulant medication other than aspirin 6. Patients with peptic ulcer disease 7. Pregnant or lactating females

Additional Information

Official title Off-Label Use of AVASTIN (BEVACIZUMAB)Intravitreal Injection For the Treatment of Serosanguinous Maculopathy
Principal investigator Chong-Lye Ang, FRCOphth
Description METHODOLOGY Patients will be recruited from the vitreoretinal clinics at SNEC. After initial assessment, clinically and angiographically, the patient will be counselled with regards to diagnosis, prognosis and management options, including the option of intravitreal Avastin. Inclusion criteria: 1. All subfoveal/juxtafoveal CNV and PCV (polypoidal choroidal vasculopathy) who are not eligible for other treatment options (compassionate use) 2. CNV and PCV lesions which have failed PDT, conventional argon laser photocoagulation (salvage use) 3. CNV and PCV lesions treatable with PDT, but cannot afford or refused Exclusion criteria: 1. Patients with uncontrolled hypertension (systolic BP greater than 150mmHg or diastolic BP greater than 90mmHg 2. History of thrombolic events such as myocardial infarction or cerebral vascular accident 3. Renal abnormalities as defined by established history of chronic renal disease or renal failure as well as patients requiring dialysis 4. Recent (as defined as the past 28 days) or planned (as defined as the next 3 months) surgery. 5. Coagulation abnormalities, including anti-coagulant medication other than aspirin 6. Patients with peptic ulcer disease 7. Pregnant or lactating females If the patient is agreeable to the intravitreal treatment protocol, he/she will be assessed systemically for fitness for the therapy. The serosanguinous maculopathy will be subtyped by angiographic findings to predominantly classic (>50% classic component) lesions, minimally classic (<50% classic component) lesions, occult lesions and polypoidal choroidal vasculopathy (PCV). If the patient is eligible for the intravitreal treatment protocol, he/she will receive 1mg of Avastin intravitreally. This will be performed under aseptic technique. (See attached 'Intravitreal Injection Protocol'). The injections will be repeated every 8-10 weeks for a total of 3 treatments. END OF TREATMENT If the central retinal thickness is reduced by >50%, or if there is imrpovement/stablisiation of vision, or if an adverse effect (such as elevation of BP) is encountered, the treating physician can elect to withhold the Avastin treatment. On review at the 8 and 16 weeks, the physician can elect to perform additional intravitreal Avastin treatment if any of the following should arise 1. Loss of VA of at least 5 letters at 2 sequential visits within 2 weeks, which is associated with increased leakage from the CNV seen on angiography or OCT 2. Increase in OCT central retinal thickness by >100um 3. Onset of a new macular haemorrhage 4. Development of a new classic CNV membrane 5. Ocular outcome measurements 6. Change from baseline in VA, i.e. gain or loss of 5 letters (1 line), 15 letters (3 lines) or 30 letters (6 lines) Secondary outcomes 1. Change in OCT measured central retinal thickness 2. Correlation in change in central retinal thickness and change in VA Once informed consent has been obtained for intravitreal Avastin therapy, the patient will be assessed for the fitness to indergo the treatment. Baseline systemic & ocular assessments will be performed. Systemic assessment will include blood pressure measurement, electrocardiogram (ECG) and blood investigations (full blood count, prothrombin time, partial thromboplastin time, bleeding time) Once deemed fit, the patient will receive Injection 1 of intravitreal Avastin (Refer Intravitreal Injection Protocol) The patient will then be reviewed at 1 week post-injection and then monthly for the first 2 months. Investigations at these visits will include logMAR BCVA, biomicroscopy, FFA and OCT. At the time point of 8-10 weeks, the patient will undergo Injection 2. Followed by review at 1 week post-injection and monthly for 2 months with the same investigations as stated above. At 16-20 weeks, the patient will receive the last treatment, Injection 3, with similar post-injection visits and investigations. If the central retinal thickness is reduced by >50%, or if there is imrpovement/stablisiation of vision, or if an adverse effect (such as elevation of BP) is encountered, the treating physician can elect to withhold the second and/or third Avastin treatment. Hence, each patient will receive at least 1 injection of Avastin and up to a maximum of 3 injections.
Trial information was received from ClinicalTrials.gov and was last updated in September 2007.
Information provided to ClinicalTrials.gov by Singapore National Eye Centre.