Overview

This trial is active, not recruiting.

Condition breast cancer
Treatment fine needle aspiration
Sponsor Carol Fabian, MD
Collaborator Intergenetics, Inc.
Start date May 2005
End date November 2016
Trial size 500 participants
Trial identifier NCT00329017, 9814

Summary

A study to examine the potential associations between common single nucleotide polymorphisms and pre-cancerous conditions in breast tissue specimens from postmenopausal women.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
Arm
Post-menopausal women who are at increased risk for development of breast cancer on the basis of family or personal history.
fine needle aspiration
Fine needle aspiration

Primary Outcomes

Measure
Correlation of SNP patterns with cytlomorphology of breast fine needle aspirates.
time frame: ongoing

Eligibility Criteria

Female participants at least 18 years old.

Inclusion Criteria: - postmenopausal women on or off hormone replacement therapy - at high risk of developing breast cancer determined by family or personal history - postmenopausal women not on hormone replacement therapy for at minimum six months prior to corresponding aspiration - willing to participate in companion protocol (KUMC HSC#4601) for random periareolar fine needle aspiration (RPFNA) for correlational studies Exclusion Criteria: - women who have been on raloxifene, tamoxifen, letrozole, anastrozole or exemestane within the six months prior to RPFNA.

Additional Information

Official title Correlation of SNP Patterns With Fine Needle Aspiration Cytomorphology in High Risk Postmenopausal Women
Principal investigator Carol J Fabian, MD
Description A study to examine the correlation between single nucleotide polymorphisms (SNPs) affecting steroid and carcinogen metabolism and benign breast tissue cytomorphology collected via random periareolar fine needle aspiration in postmenopausal women at increased risk for breast cancer and taking hormone replacement therapy.
Trial information was received from ClinicalTrials.gov and was last updated in June 2016.
Information provided to ClinicalTrials.gov by University of Kansas Medical Center.