Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer
This trial is active, not recruiting.
|Treatment||fine needle aspiration|
|Sponsor||Carol Fabian, MD|
|Start date||May 2005|
|End date||November 2016|
|Trial size||500 participants|
|Trial identifier||NCT00329017, 9814|
A study to examine the potential associations between common single nucleotide polymorphisms and pre-cancerous conditions in breast tissue specimens from postmenopausal women.
Post-menopausal women who are at increased risk for development of breast cancer on the basis of family or personal history.
Correlation of SNP patterns with cytlomorphology of breast fine needle aspirates.
time frame: ongoing
Female participants at least 18 years old.
Inclusion Criteria: - postmenopausal women on or off hormone replacement therapy - at high risk of developing breast cancer determined by family or personal history - postmenopausal women not on hormone replacement therapy for at minimum six months prior to corresponding aspiration - willing to participate in companion protocol (KUMC HSC#4601) for random periareolar fine needle aspiration (RPFNA) for correlational studies Exclusion Criteria: - women who have been on raloxifene, tamoxifen, letrozole, anastrozole or exemestane within the six months prior to RPFNA.
|Official title||Correlation of SNP Patterns With Fine Needle Aspiration Cytomorphology in High Risk Postmenopausal Women|
|Principal investigator||Carol J Fabian, MD|
|Description||A study to examine the correlation between single nucleotide polymorphisms (SNPs) affecting steroid and carcinogen metabolism and benign breast tissue cytomorphology collected via random periareolar fine needle aspiration in postmenopausal women at increased risk for breast cancer and taking hormone replacement therapy.|
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