Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression
This trial is active, not recruiting.
|Treatment||partial sleep deprivation|
|Sponsor||Zentrum für Integrative Psychiatrie|
|Collaborator||German Research Foundation|
|Start date||February 2006|
|End date||December 2008|
|Trial size||40 participants|
|Trial identifier||NCT00291239, DFG-SFB 654, C5 "IL-6-MDE", WADE|
40 patients with the diagnosis of major depression are included. There are two interventions: partial sleep deprivation (PSD) and normal night sleep (CTRL). Patients are randomly assigned to PSD-(2 undisturbed nights)-CTRL or CTRL-(2 undisturbed nights)-PSD. Cytokine-status, neuropsychological and psychopathometric status are assessed pre and post each interventional and control condition.
|Endpoint classification||efficacy study|
|Intervention model||crossover assignment|
Male or female participants at least 18 years old.
Inclusion Criteria: - Major depression - Informed consent Exclusion Criteria: - Known epilepsy or previous unexplained loss of consciousness after sleep deprivation - Bipolar disorder - Acute or chronic inflammatory diseases - Psychosis - Suicidal tendency - Pregnancy or nursing
|Official title||Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression|
|Principal investigator||Dunja Hinze-Selch, MD|
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