This trial is active, not recruiting.

Condition breast cancer
Treatments cyclophosphamide, doxorubicin hydrochloride, adjuvant therapy, radiation therapy
Phase phase 1/phase 2
Sponsor Sidney Kimmel Comprehensive Cancer Center
Collaborator National Cancer Institute (NCI)
Start date July 2004
End date May 2015
Trial size 42 participants
Trial identifier NCT00278109, J0381 CDR0000446085, JHOC-04032201, JHOC-J0381, P30CA006973


RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cyclophosphamide and doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with cyclophosphamide and doxorubicin after surgery may kill any tumor cells that remain.

PURPOSE: This phase I/II trial is studying the side effects of radiation therapy when given together with cyclophosphamide and doxorubicin and to see how well they work in treating women with stage I or stage II breast cancer who have undergone surgery.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation non-randomized
Endpoint classification safety/efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment
doxorubicin hydrochloride
adjuvant therapy
radiation therapy

Primary Outcomes

Potential acute, late skin, and subcutaneous toxicity
time frame: 1 year
Local control rate
time frame: 1 year
Cosmetic effects
time frame: 1 year

Eligibility Criteria

Female participants at least 39 years old.

DISEASE CHARACTERISTICS: - Histologically confirmed adenocarcinoma of the breast by routine hematoxylin and eosin (H&E) staining - Primary tumor ≤ 4 cm and 0-3 positive axillary lymph nodes (pathologic T1-2, pathologic N0-N1, M0) - Patients with lymph nodes positive only by cytokeratin staining (i.e., H&E negative) are eligible - No squamous cell carcinoma or sarcoma of the breast - Patients must have undergone a segmental mastectomy (SM) with a level I and ll axillary dissection or sentinel lymph node biopsy within the past 14 weeks - Surgical margins at the time of SM must be negative (> 3 mm) for both invasive carcinoma and for non-invasive ductal carcinoma - No active local-regional disease - Hormone receptor status not specified PATIENT CHARACTERISTICS: - ECOG performance status 0-1 - Sex: female - Menopausal status not specified - Not pregnant - Negative pregnancy test - Fertile patients must use effective non-hormonal contraception - No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix - No other serious or poorly controlled medical or psychiatric condition that could be exacerbated by, or complicate compliance with study treatment PRIOR CONCURRENT THERAPY: - No prior radiation therapy to the breast - No prior trastuzumab (Herceptin ®) - No other concurrent chemotherapy - No concurrent hormonal therapy except the following: - Steroids given for adrenal failure - Hormones administered for non-disease-related conditions (e.g., insulin for diabetes, synthroid for hypothyroidism) - Intermittent dexamethasone as an antiemetic or premedication

Additional Information

Official title Phase I/II Partial Breast Irradiation With Concurrent Chemotherapy
Description OBJECTIVES: - Assess the potential acute and late skin and subcutaneous toxicities in women with resected stage I or II breast cancer treated with partial breast irradiation (PBI) and concurrent cyclophosphamide/doxorubicin (AC) chemotherapy. - Assess the cosmetic effects of partial breast irradiation/chemotherapy (PBIC) in these patients. - Assess the local control rate in patients treated with this regimen. OUTLINE: Patients undergo partial breast radiotherapy once daily, 5 days a week, for 3 weeks. Patients also receive doxorubicin IV over 15 minutes and cyclophosphamide IV over 30 minutes on day 1. Treatment with doxorubicin and cyclophosphamide repeats every 2 weeks for up to 4 courses in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed periodically for approximately 10 years. PROJECTED ACCRUAL: A total of 42 patients will be accrued for this study.
Trial information was received from ClinicalTrials.gov and was last updated in March 2014.
Information provided to ClinicalTrials.gov by Sidney Kimmel Comprehensive Cancer Center.