This trial is active, not recruiting.

Conditions brain and central nervous system tumors, childhood germ cell tumor, extragonadal germ cell tumor, ovarian cancer
Treatments bleomycin sulfate, carboplatin, etoposide, conventional surgery
Sponsor Children's Cancer and Leukaemia Group
Start date April 1989
Trial size 100 participants
Trial identifier NCT00276718, CCLG-GC-1989-01, CDR0000454749, EU-20583


RATIONALE: Drugs used in chemotherapy, such as etoposide, carboplatin, and bleomycin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Giving chemotherapy drugs before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving combination chemotherapy after surgery may kill any tumor cells that remain.

PURPOSE: This clinical trial is studying how well giving etoposide, carboplatin, and bleomycin works in treating young patients undergoing surgery for malignant germ cell tumors.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Masking open label
Primary purpose treatment

Eligibility Criteria

Male or female participants up to 15 years old.

DISEASE CHARACTERISTICS: - Histologically proven malignant germ cell tumors at all stages - Testicular tumors - Stage I - Confined to testes - Stage II - Confined to testes and retroperitoneal/abdominal lymph nodes - Stage III - Supradiaphragmatic nodal disease (mediastinal and/or supraclavicular) - Stage IV - Extralymphatic spread (liver, lung, bone, brain, skin, etc.) - Ovarian, uterine, vaginal, and sacrococcygeal tumors - Stage I - Confined to ovary/uterus/vagina/pre- and postsacral area - Stage II - Spread limited to the pelvis - Stage III - Spread limited to the abdomen (excluding liver) - Stage IV - Spread to liver or beyond the abdominal cavity - Abdominal, retroperitoneal, and thoracic primary tumors - Stage I - Confined to site of origin and resectable - Stage II - Local spread - Stage III - Extensive spread confined to one side of the diaphragm (excluding the liver) - Stage IV - Tumor spread to the liver, to both sides of the diaphragm, and/or to bones, bone marrow, brain, etc. - Intracranial germ cell tumor cases allowed even if an alternative protocol is being followed PATIENT CHARACTERISTICS: - Not specified PRIOR CONCURRENT THERAPY: - No prior chemotherapy

Additional Information

Official title Germ Cell Tumour Study II
Description OBJECTIVES: - Determine the toxic effects of etoposide, carboplatin, and bleomycin in young patients with malignant germ cell tumors. OUTLINE: Patients are assigned to one of two treatment arms based on their tumor type (testicular vs ovarian, uterine, vaginal, sacrococcygeal, retroperitoneal, or thoracic). - Group 1 (testicular tumors): Patients undergo radical orchiectomy. Patients with stage I tumors and alpha-fetoprotein (AFP) decreasing at the expected rate receive no further treatment unless there is a subsequent rise in the AFP or a clinical recurrence. Patients with stage II-IV tumors receive etoposide IV over 1 hour on days 1-3, carboplatin IV over 1 hour on day 2, and bleomycin IV over 15 minutes on day 3. Treatment repeats every 21- 28 days for at least 4 courses in the absence of disease progression or unacceptable toxicity. Residual teratoma may be removed, if indicated, after completion of chemotherapy. - Group 2 (ovarian, uterine, vaginal, sacrococcygeal, retroperitoneal, or thoracic germ cell tumors): Patients undergo surgical removal or biopsy of the tumor. Patients then receive etoposide, carboplatin, and bleomycin as above. Patients may then undergo further surgery at the discretion of the principal investigator. After completion of study treatment, patients are followed periodically. PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study.
Trial information was received from ClinicalTrials.gov and was last updated in September 2013.
Information provided to ClinicalTrials.gov by National Cancer Institute (NCI).