This trial is active, not recruiting.

Conditions migraine without aura, chronic tension-type headache
Treatment eec-techniques
Sponsor Danish Headache Center
Trial identifier NCT00263991, KA 05085


Primary headache disorders are now accepted as physiological diseases, and advanced imaging-techniques have demonstrated a migraine generator in the brain stem and increased stimulus sensitivity in these patients. The underlying neuronal dysfunctions remain to to clarified and the existing neurophysiological methods have not yet been useful. More sensitive and reliable methods are therefore highly needed. The aims of the study are therefore to develop a sensitive and reliable method to demonstrate a cortical reorganisation and expansion of pain sensitive cortical areas in patients with migraine or tension-type headache.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model case control
Primary purpose screening
Time perspective cross-sectional

Eligibility Criteria

Male or female participants from 18 years up to 65 years old.

Inclusion Criteria: - Clinical diagnosis og migraine without aura or chronic tension-type headache Exclusion Criteria: - serious somatic or psychiatric diseases including depression - overuse of analgesics - regular intake of opiates or benzodiazepines - intake of prophylactic headache medication - pregnancy

Additional Information

Official title Cortical Reorganisation in Patients With Primary Headache Disorders
Principal investigator Lars Bendtsen, MD, Ph.d
Trial information was received from ClinicalTrials.gov and was last updated in December 2005.
Information provided to ClinicalTrials.gov by Danish Headache Center.