Genetics of Recurrent Early Onset Major Depression
This trial is active, not recruiting.
|Sponsor||National Institute of Mental Health (NIMH)|
|Start date||October 2005|
|End date||June 2009|
|Trial size||1500 participants|
|Trial identifier||NCT00260182, DNBBS 7G-GRR, R01 MH059541, R01 MH059542, R01 MH059552, R01 MH060912, R01 MH061686-02, R01 MH075131|
This study will identify specific genes that may cause a predisposition to depression in some families.
|United States||No locations recruiting|
|Other countries||No locations recruiting|
|Palo Alto, CA||Stanford University||no longer recruiting|
|Washington, DC||Howard University||no longer recruiting|
|Chicago, IL||Rush University Medical Center||no longer recruiting|
|Iowa City, IA||University of Iowa||no longer recruiting|
|Baltimore, MD||Johns Hopkins University||no longer recruiting|
|New York, NY||Columbia University/New York State Psychiatric Institute||no longer recruiting|
Male or female participants from 21 years up to 70 years old.
Inclusion Criteria: - History of recurrent major depression - Has a parent or sibling with a history of recurrent major depression - Depression began before the age of 31 Exclusion Criteria: - Bipolar I (manic-depressive) disorder - Schizophrenia
|Official title||Genetics of Recurrent Early Onset Major Depression|
|Principal investigator||Douglas F. Levinson, MD|
|Description||Depression is a serious medical illness that is often difficult to diagnose and treat. Studies on patterns of depression within families suggest that inherited genes may cause a predisposition to the disorder. People with early onset depression often have more relatives with depression than people whose depression does not begin until later in life. It is likely that several interacting genes cause this tendency towards the disorder, rather than one specific gene. This study will serve to identify particular genes that may cause a susceptibility to depression in order to better understand the brain mechanisms involved with severe depression. In turn, this may aid in the development of new treatments for depression. Participation in this observational study will entail one interview and one blood test. Participants will be interviewed, either in person or by telephone, about their personal and family psychiatric history. The blood sample will be collected at a time and location that is convenient for the participant. Participants may also be asked to invite other family members to participate in the study. For information on a related study please follow this link: http://clinicaltrials.gov/show/NCT00005914|
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