This trial is active, not recruiting.

Conditions behavior therapy, cocaine abuse, cocaine dependence, contingency management, heroin dependence, methadone, opioid dependence
Treatment contingency management
Sponsor National Institute on Drug Abuse (NIDA)
Collaborator Johns Hopkins University
Start date October 1996
End date January 2006
Trial size 40 participants
Trial identifier NCT00249457, NIDA-13107-2, R01-13107-2


The purpose of this study is to determine whether long-term exposure to the Therapeuitc Workplace intervention could sustain drug abstinence over an extended period of time in heroin- and cocaine-dependent, unemployed, treatment-resistant young mothers.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment

Primary Outcomes

Percentage of urine samples at the assessments that were negative for cocaine, opiates, and opiates and cocaine
time frame:

Secondary Outcomes

HIV risk behaviors
time frame:
Percentage of participants employed each month
time frame:
Number of days employed each month
time frame:
Percentage of participants to self-report abstinence at all time points
time frame:

Eligibility Criteria

Female participants from 18 years up to 50 years old.

Inclusion Criteria: - When originally enrolled in the study, participants were at least 18 years old, unemployed, and methadone maintenance patients of the Center for Addiction and Pregnancy (CAP) who continued to use opiates or cocaine during CAP treatment. Exclusion Criteria: - Participants were excluded if they were at risk for suicide at the time of intake or if they had serious psychiatric illness (e.g., schizophrenia).

Additional Information

Official title A Therapeutic Workplace for Drug Abusers
Principal investigator Kenneth Silverman, Ph.D.
Description The current study is a continuation of the research into the development and evaluation of a novel treatment designed to address the chronic, persistent nature of drug addiction. This treatment, called the Therapeutic Workplace, integrates abstinence reinforcement contingencies of proven efficacy into a model supported work program. Participants were paid to work or to train in the Therapeutic Workplace but had to provide drug-free urine samples to gain daily access. Forty participants were randomly assigned to a Therapeutic Workplace or usual care control group. Therapeutic Workplace participants could work for about 5 years. This study reports the effects of the intervention over a follow-up period of 8 years after treatment initiation.
Trial information was received from ClinicalTrials.gov and was last updated in November 2005.
Information provided to ClinicalTrials.gov by National Institute on Drug Abuse (NIDA).