This trial is active, not recruiting.

Condition rheumatoid arthritis
Sponsor University of California, Los Angeles
Start date January 1993
End date December 2022
Trial size 372 participants
Trial identifier NCT00240136, 91-10-435-32


The purpose of this research is to observe the effects of RA over a long period in order to learn which of the early characteristics of patients' early RA predict future joint damage and disability. We also investigate whether certain treatments can prevent or slow the development of joint damage and disability. Additionally, the costs and effects of RA on the patient are studied in order to improve the methods used to measure these effects. Clinical, demographic, radiographic, and laboratory measures are taken by the rheumatologist in the office. In addition, patient questionnaires are mailed & completed by the patient and returned to the coordinating center at UCLA. All information obtained by these means will be studied in their effects on early, severe RA.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort

Primary Outcomes

Development of joint erosions in the early stages of RA
time frame: Baseline, Annual Follow-up

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - >=6 swollen joints & >=9 tender joints - symmetrical rheumatoid arthritis (RA) - <= 2 years worth of symptoms - rheumatoid factor seropositivity Exclusion Criteria: - <18 years old - Inability to see rheumatologist, complete questionnaires (lack of compliance) - >2 years worth of symptoms

Additional Information

Official title Long-term Observation of Patients With Early Rheumatoid Arthritis
Principal investigator Harold E Paulus, MD
Description See Publications
Trial information was received from ClinicalTrials.gov and was last updated in February 2016.
Information provided to ClinicalTrials.gov by University of California, Los Angeles.