This trial is active, not recruiting.

Condition congenital heart disease
Sponsor Children's Healthcare of Atlanta
Start date April 2005
Trial size 20 participants
Trial identifier NCT00238810, 05.068


The purpose of this study is to assess brain natriuretic peptide levels to evaluate the relationship of those levels with the diagnosis of congenital cardiac disease, operation performed, post-operative course, and outcome.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Time perspective retrospective

Eligibility Criteria

Male or female participants of any age.

Inclusion Criteria: - Congenital heart defect Exclusion Criteria: - Patients without congenital heart defects

Additional Information

Official title Retrospective Evaluation of Serum B-type Natriuretic Peptide Hormone Levels in Post-operative Patients and the Relationship of BNP Levels to Cardiac Diagnosis, Operation Performed, Post-operative Course and Outcome
Principal investigator Alecia Wang, MD
Description Three types of natriuretic peptides (NP) have been isolated: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). The NP family elicits a number of vascular, renal and endocrine effects that help to maintain blood pressure and extracellular fluid volume. These effects are mediated by the specific binding of NP to cell surface receptors that have been characterized, purified and cloned from cells of the vasculature, kidney, adrenal gland and brain. There are 3 subtypes of NP receptors: type A natriuretic peptide receptor (NPRA), type B natriuretic peptide receptor (NPRB), and type C natriuretic peptide receptor (NPRC). All 3 subtypes affect cellular second messenger activity. The literature currently does not define the levels of b-type natriuretic peptide (BNP) in children with congenital heart disease undergoing surgery. The investigator wishes to perform a retrospective chart review to define BNP levels in the pediatric cardiac defect population and to evaluate the relationship of those levels with cardiac diagnosis, operation performed, post-operative course and outcome. The investigator will collect the following information from the medical record: - Laboratory: BNP levels, serum pH, lactic acid, Co-ox, CBC, Chemistry - Diagnosis - Surgical Procedure - Incidence of re-operation - Length of ICU Stay - Length of Hospital Stay - Complications - Length of Ventilation (how many days on the ventilator) - Medications - Cross Clamp Time - Bypass Time - Echocardiogram data - Cardiac Catheterization Data - Vital Signs - Monitored Hemodynamic Measures - Final outcome (discharged or death)
Trial information was received from ClinicalTrials.gov and was last updated in March 2012.
Information provided to ClinicalTrials.gov by Children's Healthcare of Atlanta.