Identification and Analysis of Immunomodulatory Molecules in Patients With Hematologic Disorders and Healthy Volunteers
This trial is active, not recruiting.
|Conditions||hematologic diseases, healthy volunteers|
|Treatment||isolation of genomic dna|
|Sponsor||The University of Texas Health Science Center at San Antonio|
|Collaborator||VA Office of Research and Development|
|Start date||March 2005|
|End date||August 2017|
|Trial size||1000 participants|
|Trial identifier||NCT00223483, HSC20040268H|
This research study goal is to analyze the plasma and the cells that make up part of the immune system. We want to learn how the plasma and cells work. These may influence why one person will develop an infection and another will not, or why one person develops severe symptoms of a disease while others remain without symptoms.
|United States||No locations recruiting|
|Other countries||No locations recruiting|
|San Antonio, TX||Department of Veterans Affairs, South Texas Veterans Health Care System, Audie L. Murphy Memorial Veterans Hospital Division||no longer recruiting|
|San Antonio, TX||The University of Texas Health Science Center at San Antonio||no longer recruiting|
Repository collection of plasma and serum for future analysis.
time frame: 12 years
Male or female participants at least 18 years old.
- Must be able to give blood
- Must be able to give informed consent
- Signed, written informed consent
- Individuals with a history severe anemia, inadequate venous access, severe blood or coagulation disorders.
- Pregnant women are excluded because it is a unique immunotolerant state and will alter the profile of immunomodulatory molecules.
|Official title||Identification and Analysis of Immunomodulatory Molecules From Leukocytes in Patients With Hematologic Disorders and Healthy Volunteers|
|Description||This research study goal is to analyze the plasma and the cells that make up part of the immune system. These cells, called white cells or leukocytes, are present in blood. We want to learn how these cells work to prevent infection and how they respond after an infection occurs. We also want to study certain molecules present on the plasma, on or in these cells, and the genetic material that allows these molecules to be made. These molecules may influence why one person will develop an infection and another will not, or why one person develops severe symptoms of a disease while others remain without symptoms. This study may increase our understanding of a variety of diseases including infections such as HIV, allergic diseases such as asthma, joint diseases such as rheumatoid arthritis, certain cancers, and the rejection process that sometimes occurs after transplantation of an organ.|
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