Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer
This trial is active, not recruiting.
|Start date||March 2004|
|End date||September 2008|
|Trial size||130 participants|
|Trial identifier||NCT00220246, EOMSD2004|
Two major genetic pathways leading to colorectal carcinoma can well be distinguished; the 'suppressor pathway', which is characterized by inactivation of tumor-suppressor genes and the 'mutator pathway', which is characterized by microsatellite instability. The purpose of this study is to explore a third putative pathway; microsatellite and chromosome stable colorectal cancer where an alternative cancer-causative mechanism might play a role.
|Observational model||defined population|
Male or female participants up to 51 years old.
Inclusion Criteria: - Colorectal cancer before the age of 51 years Microsatellite stable tumor Exclusion Criteria: -
|Principal investigator||Nicoline Hoogerbrugge, MD, PhD|
|Description||Patients with familial colorectal cancer will be characterized with respect to family history, medical history and demographic characteristics. The histopathology of the tumors will be reviewed. Tumor specimens will be analysed on molecular defects.|
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