Overview

This trial is active, not recruiting.

Condition colorectal neoplasms
Sponsor Radboud University
Start date March 2004
End date September 2008
Trial size 130 participants
Trial identifier NCT00220246, EOMSD2004

Summary

Two major genetic pathways leading to colorectal carcinoma can well be distinguished; the 'suppressor pathway', which is characterized by inactivation of tumor-suppressor genes and the 'mutator pathway', which is characterized by microsatellite instability. The purpose of this study is to explore a third putative pathway; microsatellite and chromosome stable colorectal cancer where an alternative cancer-causative mechanism might play a role.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model defined population
Primary purpose screening
Time perspective longitudinal

Eligibility Criteria

Male or female participants up to 51 years old.

Inclusion Criteria: - Colorectal cancer before the age of 51 years Microsatellite stable tumor Exclusion Criteria: -

Additional Information

Principal investigator Nicoline Hoogerbrugge, MD, PhD
Description Patients with familial colorectal cancer will be characterized with respect to family history, medical history and demographic characteristics. The histopathology of the tumors will be reviewed. Tumor specimens will be analysed on molecular defects.
Trial information was received from ClinicalTrials.gov and was last updated in February 2007.
Information provided to ClinicalTrials.gov by Radboud University.