Overview

This trial is active, not recruiting.

Conditions metabolic syndrome x, insulin resistance, obesity, cardiovascular diseases
Treatment ortho tri cyclen
Phase phase 4
Sponsor Virginia Commonwealth University
Start date June 2005
End date June 2009
Trial size 36 participants
Trial identifier NCT00205504, AD Williams

Summary

Oral contraceptives (OCs) are the most widely used method of reversible birth control. However, the long-term cardiovascular safety of the widely used low-dose OCs (ethinyl-estradiol < 50 mcg) is still debated. Although cardiovascular events are rare in young women whether they use OCs or not, the risks of myocardial infarction and ischemic stroke are increased among users of OCs who have conventional cardiovascular risk factors such as use of tobacco, diabetes or hypercholesterolemia. However, the risk of cardiovascular events in OC users with emerging cardiovascular risk factors (such as obesity and the metabolic syndrome) have not been investigated. Recently, the metabolic syndrome has been linked with the risk of cardiovascular disease. The syndrome is a clustering of risk factors in a single individual, and its underlying cause may be insulin resistance. Whether the metabolic syndrome predicts a higher cardiovascular risk in OC users has not been studied. This is a critical problem because the metabolic syndrome is prevalent in 24% of adults. Until the cardiovascular risks in users of OC are clearly defined, the appropriate use of OC with the least harm would not be possible.

The investigator's long-term goal is to understand the best way to prevent and treat cardiovascular disease in women. The objective of this particular project is to obtain pilot data on the extent to which the metabolic syndrome and obesity affects glucose metabolism and cardiovascular risks in women taking OCs. The researchers hypothesize that women with metabolic syndrome and obese women will have worsened glucose metabolism and elevated cardiovascular risks associated with OC use, when compared to normal weight women without the metabolic syndrome. Results of this study will clarify the risk factors for cardiovascular events in women taking OCs, and will serve as pilot data for a National Institutes of Health (NIH) proposal. Once the cardiovascular risk factors of OC users are understood, clinicians can make better informed decisions about contraceptive choices for their patients.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation non-randomized
Endpoint classification safety study
Intervention model parallel assignment
Masking open label
Primary purpose prevention
Arm
(Active Comparator)
ortho tri cyclen
Ortho Tri Cyclen, one tablet daily, for 6 cycles
(Active Comparator)
ortho tri cyclen
Ortho Tri Cyclen, one tablet daily, for 6 cycles
(Active Comparator)
ortho tri cyclen
Ortho Tri Cyclen, one tablet daily, for 6 cycles

Primary Outcomes

Measure
Changes in Insulin Sensitivity Associated With Oral Contraceptive (OC) Use Compared Among (1) Obese Women and (2) Lean Women
time frame: Baseline and 6 months

Secondary Outcomes

Measure
Changes in Lipid Profile Compared Associated With OC Use Among (1) Obese Women and (2) Lean Women
time frame: Baseline and 6 months
Inflammatory Marker Changes, High Sensitive C-reactive Protein (Hs-CRP) and Adiponectin, Associated With OC Use Compared Among (1) Obese Women and (2) Lean Women
time frame: Baseline and 6 months
Changes in Estrogen Metabolites (Plasma) Associated With OC Use Compared Among (1) Obese Women and (2) Lean Women
time frame: Baseline and 6 months
Changes in Waist-to-Hip Ratio Associated With OC Use Compared Among (1) Obese Women and (2) Lean Women
time frame: Baseline and 6 months
Inflammatory Marker Changes (MCP-1) Associated With OC Use Compared Among (1) Obese Women and (2) Lean Women
time frame: Baseline and 6 months
Changes in Blood Pressure Associated With OC Use Compared Among (1) Obese Women and (2) Lean Women
time frame: Baseline and 6 months
Changes in Body Mass Index (BMI) Associated With OC Use Compared Among (1) Obese Women and (2) Lean Women
time frame: Baseline and 6 months
Changes in Waist Circumference Associated With OC Use Compared Among (1) Obese Women and (2) Lean Women
time frame: Baseline and 6 months
Inflammatory Marker Changes, Soluble Vascular Cell Adhesion Molecule (sVCAM) and Soluble Intercellular Adhesion Molecule (sICAM), Associated With OC Use Compared Among (1) Obese Women and (2) Lean Women
time frame: Baseline and 6 months

Eligibility Criteria

Female participants from 18 years up to 40 years old.

Inclusion Criteria: 1. Acceptable health based on interview, medical history, physical examination, and laboratory tests (comprehensive metabolic panel - SMA20, and complete blood count - CBC); 2. Have not taken oral contraceptives (OCs) in the past 3 months; 3. Ability to comply with the requirements of the study; 4. Ability and willingness to provide signed, witnessed informed consent. In addition, women with the metabolic syndrome must meet the National Cholesterol Education Program (NCEP) defined criteria of the metabolic syndrome, that is, having at least 3 of the 5 factors: 1. increased waist circumference > 35 inches, 2. hypertriglyceridemia ≥ 150 mg/dL, 3. low high-density lipoprotein (HDL) cholesterol < 50 mg/dL in women, 4. hypertension (≥ 130/≥ 85 mmHg), 5. fasting glucose ≥ 100 mg/dL. Obese women with or without the metabolic syndrome should have a Body Mass Index (BMI) > 30 kg/m2 and lean women should have a Body Mass Index BMI < 25 kg/m2. Exclusion Criteria: 1. Diabetes mellitus by fasting glucose or a 2-hour oral glucose tolerance test (OGTT); 2. Clinically significant pulmonary, cardiac (including but not limited to ischemic heart disease, stable/unstable angina, and congestive heart failure), renal, hepatic, cholestatic, neurologic, psychiatric, infectious, and malignant disease (other than melanoma skin cancer); 3. History of thromboembolism, myocardial infarction, cerebrovascular accident, vascular disease, known coagulopathy, prolonged immobilization, or recent major surgery (within past 6 months); 4. Systolic blood pressure greater than 160 mmHg or diastolic blood pressure greater than 100 mmHg (mild hypertension is not an exclusion criterion); 5. History of breast cancer, migraine headaches, or age ≥ 35 years and smoker of ≥ 20 cigarettes/day; 6. Use of metformin, thiazolidinediones, anti-hyperlipidemic drugs, anti-hypertensive drugs, glucocorticoids, or anti-androgens (spironolactone, flutamide, etc.) within 3 months; 7. Documented or suspected illicit drug abuse or alcoholism within one year; 8. Ingestion of any investigational drugs within 3 months prior to the study onset; and 9. Pregnancy or lactation (≤ 6 weeks postpartum); 10. Hematocrit < 33g/dL. These exclusion criteria are based on study requirements and also go beyond guidelines for OC use published by the World Health Organization.

Additional Information

Official title Oral Contraceptives in the Metabolic Syndrome
Principal investigator Kai I Cheang, Pharm.D.
Trial information was received from ClinicalTrials.gov and was last updated in May 2013.
Information provided to ClinicalTrials.gov by Virginia Commonwealth University.