Childhood Origins of Asthma (COAST)
This trial is active, not recruiting.
|Sponsor||University of Wisconsin, Madison|
|Collaborator||National Institutes of Health (NIH)|
|Start date||October 1998|
|End date||May 2018|
|Trial size||300 participants|
|Trial identifier||NCT00204841, 1998-129, P01HL070831|
Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.
Evaluate the children longitudinally for the inception and progression of asthma.
time frame: Birth through puberty.
Male or female participants up to 2 minutes old.
- children who had one or more parent with a history of allergy or asthma
- pre term infants
- low birth weight infants
- respiratory distress at birth
|Official title||Rhinovirus Infection and Asthma in Childhood and Adolescents|
|Principal investigator||Robert F Lemanske, Jr., MD|
|Description||No more description necessary.|
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