The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney
This trial is active, not recruiting.
|Treatment||oxidative stress in kidney transplant recipients|
|Sponsor||Uniwersytet Mikolaja Kopernika w Toruniu|
|Start date||April 2003|
|End date||September 2005|
|Trial size||60 participants|
|Trial identifier||NCT00204178, KB/38/2003|
Measurement of reactive oxygen species production and antioxidant system status before and directly after reperfusion of the transplanted kidney and influence of oxidant stress on kidney function in 2 and 6 weeks.
|Observational model||defined population|
Male or female participants at least 18 years old.
- consecutive patients accepted for and undergoing cadaveric kidney transplantation
- no informed consent
|Official title||The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney|
|Description||Oxidative stress is one of the most important factors in ischaemia-reperfusion injury to the transplanted organ. In kidney transplant recipients following factors were measured: glutathione level, activities of glutathione peroxidase (GSH-PX), catalase (CAT) and superoxide dismutase (SOD) and superoxide anion production by granulocytes in whole blood without and after the stimulation with zymosan. Blood was sampled from peripheral vein (before reperfusion) and directly from renal vein (5 and 15 minutes after reperfusion). Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation.|
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