Overview

This trial is active, not recruiting.

Condition kidney transplantation
Treatment oxidative stress in kidney transplant recipients
Sponsor Uniwersytet Mikolaja Kopernika w Toruniu
Start date April 2003
End date September 2005
Trial size 60 participants
Trial identifier NCT00204178, KB/38/2003

Summary

Measurement of reactive oxygen species production and antioxidant system status before and directly after reperfusion of the transplanted kidney and influence of oxidant stress on kidney function in 2 and 6 weeks.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model defined population
Time perspective cross-sectional

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - consecutive patients accepted for and undergoing cadaveric kidney transplantation Exclusion Criteria: - no informed consent

Additional Information

Official title The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney
Description Oxidative stress is one of the most important factors in ischaemia-reperfusion injury to the transplanted organ. In kidney transplant recipients following factors were measured: glutathione level, activities of glutathione peroxidase (GSH-PX), catalase (CAT) and superoxide dismutase (SOD) and superoxide anion production by granulocytes in whole blood without and after the stimulation with zymosan. Blood was sampled from peripheral vein (before reperfusion) and directly from renal vein (5 and 15 minutes after reperfusion). Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation.
Trial information was received from ClinicalTrials.gov and was last updated in November 2005.
Information provided to ClinicalTrials.gov by Uniwersytet Mikolaja Kopernika w Toruniu.