This trial is active, not recruiting.

Condition trauma
Sponsor Rigshospitalet, Denmark
Start date March 2003
End date September 2005
Trial size 380 participants
Trial identifier NCT00192907, KF 01-160/02 Main


The purpose of this study is to investigate the relationship between trauma, the immune system, biochemical changes in the first 24 h and subsequent complications and mortality

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model defined population
Time perspective longitudinal

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Clinical suspicion of multiple trauma - Age >/= 18 years - Direct referral from scene of accident Exclusion Criteria: - Major burn injury - HIV positiv - Pregnancy

Additional Information

Description The immune system plays a role in the development of complications after severe trauma, but we do not know how. Equally, biochemical changes measured in the blood after trauma (eg. bloodglucose, GC-globulin, coagulation parameters etc.) may predict the prognosis and the degree of complcations. Two significant complications are infection and organ failure, which may prolong hospitalisation and increase mortality. In the study we collected samples from blood and body surfaces to determine changes in cytokines, biochemistry, bacterial flora, and subsequent complications. We compare the changes in between groups of the cohort.
Trial information was received from ClinicalTrials.gov and was last updated in September 2005.
Information provided to ClinicalTrials.gov by Rigshospitalet, Denmark.