Cohort Study Comparing Short Daily Hemodialysis (HD) With Conventional HD
This trial is active, not recruiting.
|Conditions||end-stage renal disease, thrombocytopathy, cardiovascular diseases|
|Sponsor||Hamilton Health Sciences Corporation|
|Collaborator||St. Joseph's Healthcare Hamilton|
|Start date||October 2004|
|End date||December 2008|
|Trial size||40 participants|
|Trial identifier||NCT00182156, Nephrology Divisional Funds|
This study is examining the effects of short daily hemodialysis on platelet function, fluid volume control, arterial stiffness and patient quality of life, as compared to conventional hemodialysis.
short daily HD
Male or female participants at least 18 years old.
Inclusion Criteria: - Patient is enrolled in short daily hemodialysis program - Patient is minimum of 18 years old Exclusion Criteria: - Patient is unable to consent due to language barrier - Patient is unable to consent due to cognitive difficulties - Patient refuses consent
|Official title||Cohort Study Examining the Effects of Short Daily Hemodialysis As Compared to Conventional Hemodialysis in Outpatients Treated at St Joseph's Healthcare, Hamilton|
|Principal investigator||Azim Gangji, MD|
|Description||Bleeding is a common cause of morbidity and mortality in patients with end stage renal disease. A major cause of uremic bleeding is due to platelet dysfunction. It has been theorized that in renal failure, toxins accumulate, some of which inhibit primary hemostasis. All aspects of normal platelet function are affected. Platelet function has previously been difficult to quantify but recently a novel test, the platelet function analyzer (PFA-100) has been determined to be both sensitive and specific in assessing platelet function. Conventional hemodialysis (CHD) has been shown to partially correct thrombocytopathy. Enhanced uremic clearance can now be attained through the use of short daily hemodialysis (SDHD). Cardiovascular disease is the most common cause of mortality in dialysis patients, accounting for 40% of deaths. Volume overload is associated with high blood pressure, left ventricular hypertrophy and elevated markers of inflammation and these factors have been associated with increased cardiovascular mortality. SDHD has been shown to control blood pressure and limit volume expansion. Pulse wave velocity (PWV) has been used to assess arterial compliance and reduction of arterial elasticity of large and small arteries which have been associated with cardiovascular outcomes.|
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