Prone Breast Irradiation for Pendulous Breasts
This trial is active, not recruiting.
|Sponsor||Maastricht Radiation Oncology|
|Collaborator||Maastricht University Medical Center|
|Start date||December 2003|
|End date||January 2010|
|Trial size||10 participants|
|Trial identifier||NCT00181363, P03.1446L|
We hypothesize that for large pendulous breasts, breast irradiation in supine and prone position are equivalent with regard to coverage of the PTV, but with a better dose homogeneity in prone position and a smaller radiation exposure of lung and heart.The purpose of this study is to compare the 3-D dose distribution in PTV and normal tissues in prone position versus supine position.
|Endpoint classification||safety/efficacy study|
|Intervention model||single group assignment|
In 10 patients a conventional simulation will be done in supine and prone position. A planning CT-scan will be obtained in both positions. A lead wire will be placed around the palpable breast tissue as an aid in the delineation.
Volume of the CTV (cc),Maximum dose delivered in at least 1 cc,Minimum dose in PTV, delivered in at least 1% of the PTV
PTV coverage (% of PTV < 95% of prescribed dose),Doses in organs at risk (heart: V30, V40, V50, lung: V20, MLD)
Female participants at least 18 years old.
Inclusion Criteria: - Patients should have had breast-conserving surgery for breast cancer or DCIS - No indication for radiotherapy of regional nodes - Large, pendulous breasts (bra size D and over) Exclusion Criteria: - Regional radiotherapy is indicated - Unable to lie in prone position
|Official title||Mamma Board Project: Prone Breast Irradiation for Pendulous Breasts|
|Principal investigator||Jeroen Buijsen, MD|
|Description||Local excision followed by adjuvant radiotherapy has become standard treatment for women with early-stage breast cancer. Adjuvant radiotherapy may encounter technical difficulties in patients with pendulous breasts when treated in supine position. Based upon literature and our own preliminary experiences, we hypothesize that for large pendulous breasts, breast irradiation in supine and prone position are equivalent with regard to coverage of the PTV, but with a better dose homogeneity in prone position and a smaller radiation exposure of lung and heart. However, no quantitative data are yet available to test this hypothesis. Therefore, the aim of our study is to compare the 3-D dose distribution in PTV and normal tissues in prone position versus supine position.|
Call for more information